2-(2,2,2-Trifluoroethoxy)phenylboronic acid

Base Information

• Chemical Name: 2-(2,2,2-Trifluoroethoxy)phenylboronic acid
• CAS No.: 957060-90-1
• Molecular Formula: C8H8BF3O3
• Molecular Weight: 219.956
• Hs Code.: 2931900090
• Mol file: 957060-90-1.mol

Synonyms:2-(2,2,2-trifluoroethoxy)phenyl]boronicaci;2-(2,2,2-Trifluoroethoxy)benzeneboronicacid98%;B-[2-(2,2,2-Trifluoroethoxy)phenyl]boronic acid;Boronic acid,B-[2-(2,2,2-trifluoroethoxy)phenyl]-

Chemical Property of 2-(2,2,2-Trifluoroethoxy)phenylboronic acid

Chemical Property:

• Vapor Pressure: 0.000315mmHg at 25°C
• Melting Point: 125-128℃
• Boiling Point: 307.4°C at 760 mmHg
• Flash Point: 139.7°C
• PSA: 49.69000
• Density: 1.35g/cm³
• LogP: 0.30750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-(2,2,2-Trifluoroethoxy)phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,2,2-Trifluoroethoxy)phenylboronic acid

There total 1 articles about 2-(2,2,2-Trifluoroethoxy)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-bromo-2-(2,2,2-trifluoroethoxy)benzene (218610-57-2) + isopropoxyboronic acid (52732-22-6) → (2-(2,2,2-trifluoroethoxy)phenyl)boronic acid (957060-90-1)

Guidance literature:

With isopropylmagnesium chloride; In 2-methyltetrahydrofuran; at -15 - -10 ℃; for 1h; Reagent/catalyst; Inert atmosphere;

Reference yield:

(2-(2,2,2-trifluoroethoxy)phenyl)boronic acid (957060-90-1) + 1-methyl-N-(4-(morpholin-4-yl)phenyl)-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-3-carboxamide → 1-methyl-N-(4-(morpholin-4-yl)phenyl)-4-oxo-5-(2-(2,2,2-trifluoroethoxy)phenyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-3-carboxamide

Guidance literature:

With pyridine; copper diacetate; triethylamine; In N,N-dimethyl-formamide; acetonitrile; at 50 ℃; for 5h;

Reference yield:

ethyl 1-(3-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate (209958-56-5) + (2-(2,2,2-trifluoroethoxy)phenyl)boronic acid (957060-90-1) → C21H19F3N2O3 (1252935-01-5)

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In propan-1-ol; water; Reflux;

DOI:10.1016/j.bmcl.2010.07.080

upstream raw materials:

1-bromo-2-(2,2,2-trifluoroethoxy)benzene

isopropoxyboronic acid

Downstream raw materials:

C₂₁H₁₉F₃N₂O₃

Refernces