[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

Base Information

Chemical Name:[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid
CAS No.:1351973-25-5
Molecular Formula:C₃₆H₃₈ClNO₃S
Molecular Weight:600.222
Hs Code.:

[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

Synonyms:

Suppliers and Price of [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MethoxyMontelukast
100mg
$ 350.00

Total 1 raw suppliers

Chemical Property of [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

Chemical Property:

Purity/Quality:: MethoxyMontelukast ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Methoxy Montelukast is an impurity of Montelukast (M568000), a selective leukotriene D4-receptor antagonist. It is used as an antiasthmatic.

Technology Process of [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

There total 13 articles about [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₄₀ClNO₃S

: 1351973-25-5
[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 10 - 55 ℃; for 5h;

Reference yield:

: 918972-54-0
[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-[1-(1-methyl)ethenyl]phenyl]propyl]thio]methyl]cyclopropaneacetic acid

: 1351973-25-5
[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethyl acetate / 25 - 30 °C

2.1: sulfuric acid; water / 5 - 10 °C

3.1: ethyl acetate / 25 - 30 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

4.2: 2.5 h / 0 - 5 °C

5.1: water; sodium hydroxide / methanol / 5 h / 10 - 55 °C

With sulfuric acid; water; sodium hydride; sodium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1197374-11-0
(S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

: 1351973-25-5
[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methoxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

2.1: ethyl acetate / 25 - 30 °C

3.1: sulfuric acid; water / 5 - 10 °C

4.1: ethyl acetate / 25 - 30 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

5.2: 2.5 h / 0 - 5 °C

6.1: water; sodium hydroxide / methanol / 5 h / 10 - 55 °C

With sulfuric acid; water; sodium methylate; sodium hydride; sodium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;