(R)-tert-butyl 4-(4-hydroxybutyl)-2,2-diMethyloxazolidine-3-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 4-(4-hydroxybutyl)-2,2-diMethyloxazolidine-3-carboxylate
• CAS No.: 1166394-91-7
• Molecular Formula: C14H27NO4
• Molecular Weight: 273.37
• Hs Code.: 2934999090
• Mol file: 1166394-91-7.mol

Synonyms:(R)-tert-butyl 4-(4-hydroxybutyl)-2,2-diMethyloxazolidine-3-carboxylate

Chemical Property of (R)-tert-butyl 4-(4-hydroxybutyl)-2,2-diMethyloxazolidine-3-carboxylate

Chemical Property:

• PSA: 59.00000
• LogP: 2.45890
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl4-(4-hydroxybutyl)-2,2-dimethyloxazolidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 4-(4-hydroxybutyl)-2,2-diMethyloxazolidine-3-carboxylate

There total 7 articles about (R)-tert-butyl 4-(4-hydroxybutyl)-2,2-diMethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(S)-tert-butyl 4-(4-ethoxy-4-oxobutyl)-2,2-dimethyl-oxazolidine-3-carboxylate → (S)-tert-butyl 4-(4-hydroxybutyl)-2,2-dimethyloxazolidine-3-carboxylate (1166394-91-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.3762/bjoc.13.214

Reference yield: 78.0%

(S)-4-((E)-4-Hydroxy-but-2-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester → (S)-tert-butyl 4-(4-hydroxybutyl)-2,2-dimethyloxazolidine-3-carboxylate (1166394-91-7)

Guidance literature:

With palladium on carbon; hydrogen; In ethyl acetate; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2010.09.079

Reference yield: 39.51%

→ (S)-tert-butyl 4-(4-hydroxybutyl)-2,2-dimethyloxazolidine-3-carboxylate (1166394-91-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 15 ℃; for 2h;

upstream raw materials:

2,2-dimethoxy-propane

tert-butyl [(1S)-5-hydroxy-1-(hydroxymethyl)pentyl]carbamate

(4S)-2,2-dimethyl-3-(t-butoxycarbonyl)-4-(formylmethyl)-1,3-oxazolidine

(S,E)-tert-butyl-4-(4-ethoxy-4-oxobut-2-enyl)-2,2-dimethyloxazolidine-3-carboxylate

Downstream raw materials:

tert-butyl (4S)-4-[4-(benzyloxy)butyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

C₃₀H₄₅NO₄Si

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