(S)-2-(2-aMino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dione (Hydrochloride)

Base Information

Chemical Name:(S)-2-(2-aMino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dione (Hydrochloride)
CAS No.:1240137-75-0
Molecular Formula:C19H18Cl2N2O3
Molecular Weight:393.26382
Hs Code.:
Mol file:1240137-75-0.mol

Synonyms:(S)-2-(2-amino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dione hydrochloride;

Suppliers and Price of (S)-2-(2-aMino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dione (Hydrochloride)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-2-(2-Amino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dioneHydrochloride
50mg
$ 200.00

Total 7 raw suppliers

Chemical Property of (S)-2-(2-aMino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dione (Hydrochloride)

Chemical Property:

PSA：80.47000
LogP:3.71430

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-(2-Amino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dioneHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-2-(2-aMino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dione (Hydrochloride)

There total 4 articles about (S)-2-(2-aMino-3-(4-(2-chloroacetyl)phenyl)propyl)isoindoline-1,3-dione (Hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.1%

: 79-04-9
chloroacetyl chloride

: 187526-95-0
2-[(2S)-2-amino-3-phenylpropyl]-1H-isoindole-1,3(2H)-dione hydrochloride:

: 1240137-75-0
2-{(2S)-2-amino-3-[4-(chloroacetyl)phenyl]propyl}-1Hisoindole-1,3(2H)-dione

: 1240137-78-3
2-{(2S)-2-amino-3-[3-(chloroacetyl)phenyl]propyl}-1Hisoindole-1,3(2H)-dione

Guidance literature:: chloroacetyl chloride; 2-[(2S)-2-amino-3-phenylpropyl]-1H-isoindole-1,3(2H)-dione hydrochloride:; With aluminum (III) chloride; at -5 ℃; for 22h;

With methanol; at 35 - 50 ℃;

With hydrogenchloride; In methanol; water; at 65 ℃; for 18h; regioselective reaction;
DOI:10.1021/op100186c

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 1240137-75-0
2-{(2S)-2-amino-3-[4-(chloroacetyl)phenyl]propyl}-1Hisoindole-1,3(2H)-dione

: 1240137-78-3
2-{(2S)-2-amino-3-[3-(chloroacetyl)phenyl]propyl}-1Hisoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate / 1.5 h

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C

2.2: 2 h / 60 °C

3.1: aluminum (III) chloride / 22 h / -5 °C

3.2: 35 - 50 °C

3.3: 18 h / 65 °C

With aluminum (III) chloride; di-isopropyl azodicarboxylate; triphenylphosphine; In methanol; ethyl acetate; toluene; 2.1: Mitsunobu reaction / 3.1: Friedel Crafts acylation;
DOI:10.1021/op100186c

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 1240137-75-0
2-{(2S)-2-amino-3-[4-(chloroacetyl)phenyl]propyl}-1Hisoindole-1,3(2H)-dione

: 1240137-78-3
2-{(2S)-2-amino-3-[3-(chloroacetyl)phenyl]propyl}-1Hisoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C

1.2: 2 h / 60 °C

2.1: aluminum (III) chloride / 22 h / -5 °C

2.2: 35 - 50 °C

2.3: 18 h / 65 °C

With aluminum (III) chloride; di-isopropyl azodicarboxylate; triphenylphosphine; In methanol; toluene; 1.1: Mitsunobu reaction / 2.1: Friedel Crafts acylation;
DOI:10.1021/op100186c