3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

Base Information

Chemical Name:3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate
CAS No.:871700-32-2
Molecular Formula:C25H21FIN3O6S
Molecular Weight:637.427
Hs Code.:
Mol file:871700-32-2.mol

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

Synonyms:2,3-O-isopropylidene-D-ribofuranosylamine p-toluenesulfonate;2,3-O-isopropylideneribofuranosylamine p-toluene-sulfonate;p-Tetramethyldiamidophosphinylbenzoesaeure;p-toluenesulfonic acid 3-cyclopropyl-1-(2-fluoro-4-iodo-phenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydro-pyrido[2,3-d]pyrimidin-5-yl ester;2,3-O-isopropylidene-D-ribofuranosylamine toluene-p-sulphonate;Benzoic acid,4-[bis(dimethylamino)phosphinyl];2,3-O-isopropylideneribofuranosylammonium p-toluenesulfonate;

Suppliers and Price of 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl4-methylbenzenesulfonate 97%
100mg
$ 676.00

Matrix Scientific
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl4-methylbenzenesulfonate 97%
5g
$ 5400.00

Crysdot
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl4-methylbenzenesulfonate 95+%
5g
$ 5357.00

AK Scientific
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-D]pyrimidin-5-yl4-methylbenzenesulfonate
100mg
$ 962.00

Total 26 raw suppliers

Chemical Property of 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

Chemical Property:

PSA：117.75000
LogP:4.39500

Purity/Quality:

97% ^*data from raw suppliers

3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl4-methylbenzenesulfonate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

There total 1 articles about 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 871700-24-2
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione

: 98-59-9
p-toluenesulfonyl chloride

: 871700-32-2
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

Guidance literature:: With trimethylamine hydrochloride; triethylamine; In acetonitrile; at 0 - 20 ℃; for 4h;

Reference yield: 93.0%

: 871700-32-2
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

: 102-28-3
m-acetamide aniline

: 871700-25-3
N-{3-[3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-ylamino]phenyl}acetamide

Guidance literature:: With 2,6-dimethylpyridine; In N,N-dimethyl acetamide; at 130 ℃; for 4h; Product distribution / selectivity;

Reference yield:

: 871700-32-2
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

: 1401253-65-3
(3-aminophenyl)(azetidin-1-yl)methanone

: 1456713-68-0
1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / N,N-dimethyl acetamide / 16 h / 130 °C / Sealed tube; Inert atmosphere

2: sodium methylate / methanol; tetrahydrofuran / 1 h / 22 - 26 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium methylate; In tetrahydrofuran; methanol; N,N-dimethyl acetamide;