1-((3aS,6aR)-6-(benzyloxyMethyl)-2,2-diMethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-1H-iMidazo[4,5-c]pyridine

Base Information

Chemical Name:1-((3aS,6aR)-6-(benzyloxyMethyl)-2,2-diMethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-1H-iMidazo[4,5-c]pyridine
CAS No.:105522-07-4
Molecular Formula:C22H22ClN3O3
Molecular Weight:411.88138
Hs Code.:
Mol file:105522-07-4.mol

Synonyms:1-((3aS,6aR)-6-(benzyloxymethyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-1H-imidazo[4,5-c]pyridine;

Suppliers and Price of 1-((3aS,6aR)-6-(benzyloxyMethyl)-2,2-diMethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-1H-iMidazo[4,5-c]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 1-((3aS,6aR)-6-(benzyloxyMethyl)-2,2-diMethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-1H-iMidazo[4,5-c]pyridine

Chemical Property:

PSA：58.40000
LogP:4.30270

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-((3aS,6aR)-6-(benzyloxyMethyl)-2,2-diMethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-1H-iMidazo[4,5-c]pyridine

There total 1 articles about 1-((3aS,6aR)-6-(benzyloxyMethyl)-2,2-diMethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-1H-iMidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89291-77-0
(1S,4R,5S)-(-)-3-<(benzyloxy)methyl>-4,5-O-isopropylidene-2-cyclopenten-1-ol methanesulfonate

: 2770-01-6
4-chloro-1H-imidazo[4,5-c]pyridine

: 105522-24-5
3-((3aS,4R,6aR)-6-Benzyloxymethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-4-chloro-3H-imidazo[4,5-c]pyridine

: 105522-07-4
(-)-1-<(1R,4R,5S)-3-(Benzyloxymethyl)-4,5-O-isopropylidene-2-cyclopenten-1-yl>-4-chloroimidazo<4,5-c>pyridine

Guidance literature:: With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1) MeCN, r.t., 16 h, 2) reflux, 6 h;
DOI:10.1021/jm00127a007

Reference yield: 69.0%

: 105522-07-4
(-)-1-<(1R,4R,5S)-3-(Benzyloxymethyl)-4,5-O-isopropylidene-2-cyclopenten-1-yl>-4-chloroimidazo<4,5-c>pyridine

: 105522-08-5
(-)-1-<(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl>-4-chloroimidazo<4,5-c>pyridine

Guidance literature:: With boron trichloride; In dichloromethane; at -75 ℃; for 3.5h;
DOI:10.1021/jm00127a007

Reference yield:

: 105522-07-4
(-)-1-<(1R,4R,5S)-3-(Benzyloxymethyl)-4,5-O-isopropylidene-2-cyclopenten-1-yl>-4-chloroimidazo<4,5-c>pyridine

: 120964-45-6
3-deazaneplanocin A hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / BCl₃ / CH₂Cl₂ / 3.5 h / -75 °C

2: N₂H₄ / 1.5 h / Heating

3: 1) Raney nickel, 2) 10percent HCl / 1) water, reflux, 30 min

With hydrogenchloride; boron trichloride; nickel; hydrazine; In dichloromethane;
DOI:10.1021/jm00127a007