3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl

Base Information

• Chemical Name: 3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl
• CAS No.: 76268-12-7
• Molecular Formula: C₁₃H₁₄O₅
• Molecular Weight: 250.251

Synonyms:

Chemical Property of 3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl

There total 1 articles about 3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methanol (67-56-1) + coumarin (91-64-5) + bromoacetic acid methyl ester (96-32-2) → 3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl (76268-12-7)

Guidance literature:

methanol; coumarin; With sodium methylate; for 0.166667h; Heating;

bromoacetic acid methyl ester; for 3.5h; Further stages.; Heating;

DOI:10.1039/b000619j

Reference yield:

3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl (76268-12-7) → 3-Benzyloxycarbonylmethylbenzofuran-2-carboxylic acid benzyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / NaOMe / methanol / 0.25 h / 70 °C

2: 80 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / 5 h / Heating

3: 97 percent / DBU / CH₂Cl₂ / 1.5 h / 20 °C

4: 25 percent / p-TsOH / 14 h / Heating

With N-Bromosuccinimide; sodium methylate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; 1: Cyclization / 2: Bromination / 3: Elimination / 4: Esterification;

DOI:10.1039/b000619j

Reference yield:

3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl (76268-12-7) → methyl 2-carboxybenzofuran-3-acetate (76268-17-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 68 percent / NaOMe / methanol / 0.25 h / 70 °C

2: 80 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / 5 h / Heating

3: 56 percent / K₂CO₃; H₂O / methanol / 15 h / 20 °C

4: acetyl chloride / benzene / 5 h

5: 4 h / Heating

With N-Bromosuccinimide; water; sodium methylate; potassium carbonate; acetyl chloride; dibenzoyl peroxide; In methanol; tetrachloromethane; benzene; 1: Cyclization / 2: Bromination / 3: Hydrolysis / 4: Cyclization / 5: Esterification;

DOI:10.1039/b000619j

upstream raw materials:

methanol

coumarin

bromoacetic acid methyl ester

Downstream raw materials:

methyl 2-carboxybenzofuran-3-acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 76268-12-7 3-(2-Methoxycarbonylmethoxyphenyl)acrylic acid methyl

Send

Send

Metric Ton KG G Pound L ML

Send

Send