(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Base Information

Chemical Name:(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide
CAS No.:929095-18-1
Deprecated CAS:1000873-97-1
Molecular Formula:C₂₇H₂₈F₃N₅O₂S
Molecular Weight:543.613
Hs Code.:
UNII:8QO27TK6Q4
ChEMBL ID:CHEMBL1908394
DSSTox Substance ID:DTXSID60239197
NCI Thesaurus Code:C70948
Nikkaji Number:J2.636.663A
Pharos Ligand ID:SP1ZJ3SCZ3BY
Wikidata:Q27077906
Mol file:929095-18-1.mol

Synonyms:GSK 461364;GSK-461364;GSK461364

Suppliers and Price of (R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GSK461364
2.5mg
$ 50.00

TRC
GSK461364
5mg
$ 90.00

TRC
GSK461364
10mg
$ 170.00

Matrix Scientific
5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide 95+%
1g
$ 3990.00

Matrix Scientific
5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide 95+%
250mg
$ 1796.00

DC Chemicals
PLK1inhibitorGSK461364 >98%
250 mg
$ 1400.00

DC Chemicals
PLK1inhibitorGSK461364 >98%
100 mg
$ 700.00

Crysdot
GSK461364 98+%
10mg
$ 216.00

Crysdot
GSK461364 98+%
50mg
$ 682.00

Crysdot
GSK461364 98+%
100mg
$ 973.00

Total 36 raw suppliers

Chemical Property of (R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Chemical Property:

Appearance/Colour:White to gray solid
Boiling Point:658 °C at 760 mmHg
PKA:15.16±0.50(Predicted)
Flash Point:351.7 °C
PSA：104.86000
Density:1.39 g/cm³
LogP:5.66820
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:543.19158081
Heavy Atom Count:38
Complexity:814

Purity/Quality:

99%, ^*data from raw suppliers

GSK461364 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N
Isomeric SMILES:C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N
Recent ClinicalTrials:Study to Assess the Pharmacokinetics and Pharmacodynamics of GSK461364 in Subjects With Non-Hodgkins Lymphoma
Uses GSK 461364 is a dose-dependant inhibitor of proliferating cancer cell lines as well as an apoptotic agent at higher dosage levels.

Technology Process of (R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

There total 2 articles about (R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%