Nvp-aew541

Base Information

Chemical Name:Nvp-aew541
CAS No.:475488-34-7
Molecular Formula:C27H29N5O
Molecular Weight:439.56
Hs Code.:
UNII:97QB5037VR
ChEMBL ID:CHEMBL1614712,CHEMBL3188172
DSSTox Substance ID:DTXSID60467110
Nikkaji Number:J2.505.707D
Pharos Ligand ID:J8H449NM87NB,KJUFBBCH4BWL
Wikidata:Q27088111,Q27272024,Q27456231
Mol file:475488-34-7.mol

Synonyms:NVP-AEW541

Suppliers and Price of Nvp-aew541

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
7-[TRANS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE 95.00%
5G
$ 836.80

Total 18 raw suppliers

Chemical Property of Nvp-aew541

Chemical Property:

PSA：69.20000
Density:1.33
LogP:5.43540
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:439.23721057
Heavy Atom Count:33
Complexity:632

Purity/Quality:

98%min ^*data from raw suppliers

7-[TRANS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6

Technology Process of Nvp-aew541

There total 28 articles about Nvp-aew541 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121-71-1
3-Hydroxyacetophenone

: 475488-34-7
7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]-pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / Inert atmosphere

2: bromine; Pyridine hydrobromide / Inert atmosphere

3: hydrogenchloride; potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

4: Inert atmosphere

5: acetic anhydride / Inert atmosphere

6: ammonia / methanol / Inert atmosphere

7: sodium ethanolate / ethanol / Inert atmosphere

8: hydrogenchloride / Inert atmosphere

9: Inert atmosphere

10: Inert atmosphere

With hydrogenchloride; ammonia; bromine; sodium ethanolate; Pyridine hydrobromide; acetic anhydride; potassium carbonate; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/op700052u

Reference yield:

: 100-39-0
benzyl bromide

: 475488-34-7
7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]-pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / Inert atmosphere

2: bromine; Pyridine hydrobromide / Inert atmosphere

3: hydrogenchloride; potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

4: Inert atmosphere

5: acetic anhydride / Inert atmosphere

6: ammonia / methanol / Inert atmosphere

7: sodium ethanolate / ethanol / Inert atmosphere

8: hydrogenchloride / Inert atmosphere

9: Inert atmosphere

10: Inert atmosphere

With hydrogenchloride; ammonia; bromine; sodium ethanolate; Pyridine hydrobromide; acetic anhydride; potassium carbonate; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/op700052u

Reference yield:

: cis-3-aminocyclobutanemethyl benzoate butanedioate

: 475488-34-7
7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]-pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 10 steps

1: sodium azide / Inert atmosphere

2: hydrogenchloride; platinum on activated charcoal / methanol; tetrahydrofuran / Inert atmosphere

3: triethylamine / Inert atmosphere

4: sodium methylate / methanol / Inert atmosphere

5: ammonia / Inert atmosphere

6: sodium ethanolate / ethanol

7: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / Inert atmosphere

8: lithium aluminium tetrahydride / Inert atmosphere

9: triethylamine / tetrahydrofuran / 0.5 h / -30 - -20 °C / Inert atmosphere

10: tetrahydrofuran / 12 h / 50 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; sodium azide; 18-crown-6 ether; platinum on activated charcoal; ammonia; sodium methylate; sodium ethanolate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/op700052u