7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE

Base Information

• Chemical Name: 7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE
• CAS No.: 22246-45-3
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.201
• Hs Code.: 2933990090
• Mol file: 22246-45-3.mol

Synonyms:4,5-DIHYDRO-7-NITRO-1H-BENZO[B]AZEPIN-2(3H)-ONE;7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE;2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-7-nitro-;7-Nitro-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one;1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on

Chemical Property of 7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE

Chemical Property:

• Vapor Pressure: 1.89E-07mmHg at 25°C
• Boiling Point: 425.6°C at 760 mmHg
• Flash Point: 211.2°C
• PSA: 74.92000
• Density: 1.301g/cm³
• LogP: 2.53080
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

7-Nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE

There total 7 articles about 7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,3,4,5-tetrahydro-benzo[b]azepin-2-one sulfate (740842-78-8) → 1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on (22246-45-3)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 0 - 5 ℃; for 0.5h;

Reference yield: 78.0%

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one (4424-80-0) → 1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on (22246-45-3)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; for 0.5h;

Reference yield: 70.0%

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one (4424-80-0) → 1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on (22246-45-3) + 9-nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one + 7,9-dinitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 5 ℃;

DOI:10.1016/j.bmcl.2003.07.017

upstream raw materials:

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

1-tetralone oxime

3,4-dihydronaphthalene-1(2H)-one

1,3,4,5-tetrahydro-benzo[b]azepin-2-one sulfate

Downstream raw materials:

7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride

2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-benzamide

2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide