(R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide

Base Information

Chemical Name:(R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide
CAS No.:376594-67-1
Molecular Formula:C19H22F2N2O3S
Molecular Weight:396.458
Hs Code.:
UNII:JT47TQ8QOS
DSSTox Substance ID:DTXSID10431720
Pharos Ligand ID:A8X7TAXF4LUJ
ChEMBL ID:CHEMBL1214201
Mol file:376594-67-1.mol

Synonyms:376594-67-1;LY450108;(R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide;LY-450108;JT47TQ8QOS;LY 450108;(R)-3,5-Difluoro-N-(4-(1-(1-methylethylsulfonamido)-propan-2-yl)phenyl)benzamide;N-[4-[(1R)-1-Methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]3,5-difluorophenylcarboxamide;C19H22F2N2O3S;UNII-JT47TQ8QOS;SCHEMBL6554355;CHEMBL1214201;DTXSID10431720;BCP06875;AKOS025149442;CS-1090;NCGC00370740-02;NCGC00370740-04;AC-37082;AS-16420;HY-10935;A899641;(R)-3,5-Difluoro-N-(4-(1-((1-methylethyl)sulfonamido)propan-2-yl)phenyl)benzamide;3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)-BENZAMIDE;3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)BENZAMIDE;BENZAMIDE, 3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)-;n-[4((1r)-1-methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl](3,5-difluorophenyl)carboxamide;n-[4-((1r)-1-methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl](3,5-difluorophenyl)carboxamide

Suppliers and Price of (R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(R)-3,5-Difluoro-N-(4-(1-(1-methylethylsulfonamido)-propan-2-yl)phenyl)benzamide 97%
250mg
$ 3240.00

Matrix Scientific
(R)-3,5-Difluoro-N-(4-(1-(1-methylethylsulfonamido)-propan-2-yl)phenyl)benzamide 97%
100mg
$ 1584.00

DC Chemicals
LY450108 >98%
50 mg
$ 844.80

DC Chemicals
LY450108 >98%
10 mg
$ 290.40

Crysdot
LY450108 98+%
10mg
$ 236.00

Crysdot
LY450108 98+%
50mg
$ 687.00

Crysdot
LY450108 98+%
5mg
$ 172.00

ChemScene
LY450108 99.51%
10mg
$ 436.00

ChemScene
LY450108 99.51%
5mg
$ 286.00

ChemScene
LY450108 99.51%
50mg
$ 1267.00

Total 12 raw suppliers

Chemical Property of (R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide

Chemical Property:

PSA：83.65000
LogP:5.19310
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:396.13192007
Heavy Atom Count:27
Complexity:576

Purity/Quality:

97% ^*data from raw suppliers

(R)-3,5-Difluoro-N-(4-(1-(1-methylethylsulfonamido)-propan-2-yl)phenyl)benzamide 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)NC(=O)C2=CC(=CC(=C2)F)F
Isomeric SMILES:C[C@@H](CNS(=O)(=O)C(C)C)C1=CC=C(C=C1)NC(=O)C2=CC(=CC(=C2)F)F

Technology Process of (R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide

There total 13 articles about (R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

: 400629-26-7
[(2S)-2-(4-aminophenyl)propyl][(methylethyl)sulfonyl]amine

: 129714-97-2
3,5-difluorobenzoyl chloride

: 376594-67-1
LY 450108

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

Reference yield: 80.9%

: 129714-97-2
3,5-difluorobenzoyl chloride

: 376594-72-8
R-2-(4-nitrophenyl)-1-(2-propanesulfonamido)-propane

: 376594-67-1
LY 450108

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 376594-67-1
LY 450108

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / pyridine; cyanuric fluoride / acetonitrile / 3.5 h / 20 °C

2: 34 percent / triphenylmethane; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3: 33 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / -70 - 20 °C

4: 91 percent / sodium borohydride / tetrahydrofuran; H₂O / 3 h / 20 °C

5: 88 percent / triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / 20 °C

6: 95 percent / hydrazine / toluene / 1 h / 80 - 90 °C

7: 88 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / 20 °C

8: 88 percent / hydrogen / Pd/C / ethanol / 16 h

9: 90 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; n-butyllithium; trifluoro-[1,3,5]triazine; triphenylmethane; hydrogen; sodium hexamethyldisilazane; triethylamine; triphenylphosphine; hydrazine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene; acetonitrile; 5: Mitsunobu reaction;
DOI:10.1002/jlcr.899