UCPH-101

Base Information

• Chemical Name: UCPH-101
• CAS No.: 1118460-77-7
• Molecular Formula: C27H22N2O3
• Molecular Weight: 422.48
• Mol file: 1118460-77-7.mol

Synonyms:UCPH-101;2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile;4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-

Chemical Property of UCPH-101

Chemical Property:

• Melting Point: 194.0-197.2 °C
• Boiling Point: 703.5±60.0 °C(Predicted)
• PKA: 3.23±0.60(Predicted)
• PSA: 85.34000
• Density: 1.32±0.1 g/cm3(Predicted)
• LogP: 5.75718
• Storage Temp.: Store at +4°C
• Solubility.: Soluble in DMSO (up to 10 mg/ml).

Purity/Quality:

99% ^*data from raw suppliers

UCPH101 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: UCPH-101 is a noncompetitive inhibitor of excitatory amino acid transporter 1 (EAAT1), which takes up extracellular glutamate in the central nervous system. UCPH-1 is selective for EAAT1 over EAAT2 and EAAT3 with IC50 values of 0.66, >300, and >300 μM, respectively, in a radioligand uptake assay using HEK293 cells transfected with the human transporter. It selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 μM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 μM. UCPH-101 is orally bioavailable in rats at a dose of 10 mg/kg but does not cross the blood-brain barrier.
• Uses: UCPH 101 is a subtype-selective inhibitor of human excitatory amino acid transporter subtype 1.

Technology Process of UCPH-101

There total 1 articles about UCPH-101 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-(naphthalene-1-yl)cyclohexane-1,3-dione (144128-68-7) + 4-methoxy-benzaldehyde (123-11-5) + malononitrile (109-77-3) → 2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (1118460-77-7)

Guidance literature:

With 4-methyl-morpholine; In ethanol; at 5 - 20 ℃; for 21.5h;

DOI:10.1021/jm8013458

upstream raw materials:

5-(naphthalene-1-yl)cyclohexane-1,3-dione

4-methoxy-benzaldehyde

malononitrile

Refernces