<(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Base Information

Chemical Name:<(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
CAS No.:122648-64-0
Molecular Formula:C₂₆H₂₂Cl₂N₄O₇S
Molecular Weight:605.455
Hs Code.:

<(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Chemical Property of <(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Technology Process of <(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

There total 2 articles about <(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 343-55-5
sodium dicloxacillin

: 122648-64-0
<(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.43 g / NaHCO₃, tetrabutylammonium hydrogen sulfate / H₂O; CH₂Cl₂ / below 30 deg C

2: 1.1 g / dimethylformamide / 144 h / Ambient temperature

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00128a021

Reference yield:

: 16518-17-5
potassium nicotinate

: 122648-60-6
chloromethyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 122648-64-0
<(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; for 144h; Ambient temperature;
DOI:10.1021/jm00128a021

Reference yield:

: 122648-64-0
<(3-pyridinylcarbonyl)oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 122648-71-9
<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 0.55 g / nitromethane

2: 0.14 g / Na₂S₂O₄, NaHCO₃

With sodium dithionite; sodium hydrogencarbonate; In nitromethane;
DOI:10.1021/jm00128a021