Dicloxacillin(1-)

Base Information

Chemical Name:Dicloxacillin(1-)
CAS No.:343-55-5
Molecular Formula:C19H16Cl2N3O5S·Na
Molecular Weight:492.315
Hs Code.:
NCI Thesaurus Code:C47985
RXCUI:267257
Wikidata:Q27123097

Synonyms:Cilpen;Dichloroxacillin;Diclocil;Dicloxaciclin;Dicloxacillin;Dicloxacillin Sodium;Dicloxacillin, Monosodium Salt, Anhydrous;Dicloxacillin, Monosodium Salt, Mono-Hydrate;Dicloxacycline;Dicloxsig;Distaph;Ditterolina;Dycill;Dynapen;InfectoStaph;Pathocil;Posipen;Sodium, Dicloxacillin

Suppliers and Price of Dicloxacillin(1-)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 21 raw suppliers

Chemical Property of Dicloxacillin(1-)

Chemical Property:

Boiling Point:692.4 °C at 760 mmHg
Flash Point:372.5 °C
PSA：138.04000
LogP:3.64340
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:468.0187722
Heavy Atom Count:30
Complexity:740

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-]
Isomeric SMILES:CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-]
Uses antibacterial

Technology Process of Dicloxacillin(1-)

There total 3 articles about Dicloxacillin(1-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.21%

: 551-16-6
6-Aminopenicillanic Acid

: 4462-55-9
3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylcarbonyl chloride

: 343-55-5
sodium dicloxacillin

Guidance literature:: 6-Aminopenicillanic Acid; With sodium hydroxide; In water; at 0 - 5 ℃; for 0.333333h;

3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylcarbonyl chloride; In acetone; at 5 ℃; for 1h; pH=7;

With sodium 2-ethylhexanoic acid; In isopropyl alcohol; at 30 ℃; for 0.5h; Temperature; Solvent;

Reference yield:

: 3919-76-4
3-(2,6-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

: 343-55-5
sodium dicloxacillin

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentachloride / toluene

2: ammonium hydroxide / ethyl acetate / pH 2 - 8

With ammonium hydroxide; phosphorus pentachloride; In ethyl acetate; toluene;

Reference yield:

: 83-38-5
2,6-dichlorobenzaldehyde

: 343-55-5
sodium dicloxacillin

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine sulfate / methanol / 1 h / 20 - 40 °C

1.2: 24 h / 0 - 20 °C / pH ~ 9.5 / Inert atmosphere

1.3: pH ~ 7 - 7.5

2.1: phosphorus pentachloride / toluene

3.1: ammonium hydroxide / ethyl acetate / pH 2 - 8

With ammonium hydroxide; phosphorus pentachloride; hydroxylamine sulfate; In methanol; ethyl acetate; toluene;