2(1H)-Isoquinolinebutanoic acid, β-[[2-[3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl]acetyl]amino]-3,4-dihydro-γ-oxo-, (βS)-

Base Information

Chemical Name:2(1H)-Isoquinolinebutanoic acid, β-[[2-[3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl]acetyl]amino]-3,4-dihydro-γ-oxo-, (βS)-
CAS No.:190447-31-5
Molecular Formula:C₂₅H₂₇N₅O₅
Molecular Weight:477.52
Hs Code.:
Mol file:190447-31-5.mol

Synonyms:GUZVLHPRMOIOEW-QWAKEFERSA-N;2(1H)-Isoquinolinebutanoic acid, β-[[2-[3-[4-(aMinoiMinoMethyl)phenyl]-4,5-dihydro-5-isoxazolyl]acetyl]aMino]-3,4-dihydro-γ-oxo-, (βS)-

Suppliers and Price of 2(1H)-Isoquinolinebutanoic acid, β-[[2-[3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl]acetyl]amino]-3,4-dihydro-γ-oxo-, (βS)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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American Custom Chemicals Corporation
(BETAS)-BETA-[[2-[3-[4-(AMINOIMINOMETHYL)PHENYL]-4,5-DIHYDRO-5-ISOXAZOLYL]ACETYL]AMINO]-3,4-DIHYDRO-GAMMA-OXO-2(1H)-ISOQUINOLINEBUTANOIC ACID 95.00%
1MG
$ 877.80

Total 3 raw suppliers

Chemical Property of 2(1H)-Isoquinolinebutanoic acid, β-[[2-[3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl]acetyl]amino]-3,4-dihydro-γ-oxo-, (βS)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(BETAS)-BETA-[[2-[3-[4-(AMINOIMINOMETHYL)PHENYL]-4,5-DIHYDRO-5-ISOXAZOLYL]ACETYL]AMINO]-3,4-DIHYDRO-GAMMA-OXO-2(1H)-ISOQUINOLINEBUTANOIC ACID 95.00% ^*data from reagent suppliers

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Technology Process of 2(1H)-Isoquinolinebutanoic acid, β-[[2-[3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl]acetyl]amino]-3,4-dihydro-γ-oxo-, (βS)-

There total 11 articles about 2(1H)-Isoquinolinebutanoic acid, β-[[2-[3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl]acetyl]amino]-3,4-dihydro-γ-oxo-, (βS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 190447-31-5
β-[({3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-3,4-dihydro-γ-oxo-2(1H)-isoquinolinebutanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: TBTU, Et₃N / ethyl acetate / 18 h / Ambient temperature

2: 4 M HCl / dioxane / 1 h / Ambient temperature

3: TBTU, Et₃N / dimethylformamide / 2 h / Ambient temperature

4: 4 M HCl / dioxane / 10 h / Ambient temperature

5: 40percent conc. HCl, formic acid / Ambient temperature

With hydrogenchloride; formic acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i

Reference yield:

: 52707-54-7,52707-59-2,64847-77-4
4-cyanobenzaldehyde oxime

: 190447-31-5
β-[({3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-3,4-dihydro-γ-oxo-2(1H)-isoquinolinebutanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 34 percent / aq. NaOCl / tetrahydrofuran / Ambient temperature

2: 73 percent / HCl / 24 h / Ambient temperature

3: NH₃ / methanol / 14 h / Ambient temperature

4: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

5: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

6: TBTU, Et₃N / dimethylformamide / 2 h / Ambient temperature

7: 4 M HCl / dioxane / 10 h / Ambient temperature

8: 40percent conc. HCl, formic acid / Ambient temperature

With hydrogenchloride; lithium hydroxide; sodium hypochlorite; formic acid; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i

Reference yield:

: 170229-13-7
[3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid

: 190447-31-5
β-[({3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-3,4-dihydro-γ-oxo-2(1H)-isoquinolinebutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / HCl / 24 h / Ambient temperature

2: NH₃ / methanol / 14 h / Ambient temperature

3: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

4: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

5: TBTU, Et₃N / dimethylformamide / 2 h / Ambient temperature

6: 4 M HCl / dioxane / 10 h / Ambient temperature

7: 40percent conc. HCl, formic acid / Ambient temperature

With hydrogenchloride; lithium hydroxide; formic acid; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i