Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-[(1S)-1-phenylethyl]-

Base Information

• Chemical Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-[(1S)-1-phenylethyl]-
• CAS No.: 427877-76-7
• Molecular Formula: C₂₅H₂₆N₆O₃
• Molecular Weight: 458.52

Synonyms:4-[[5-[(Methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide;

Chemical Property of Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-[(1S)-1-phenylethyl]-

Chemical Property:

• PSA: 109.65000
• LogP: 4.72670

Purity/Quality:

4-[[5-[(METHOXYAMINO)CARBONYL]-2-METHYLPHENYL]AMINO]-5-METHYL-N-[(1S)-1-PHENYLETHYL]-PYRROLO-[2,1-F]-[1,2,4]TRIAZINE-6-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-[(1S)-1-phenylethyl]-

There total 1 articles about Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-[(1S)-1-phenylethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid (1005196-62-2) + (S)-(-)-α-methylbenzylamine hydrochloride (17279-30-0) → (S)-4-(5-(methoxycarbamoyl)-2-methylphenylamino)-5-methyl-N-(1-phenylethyl)pyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (427877-76-7)

Guidance literature:

4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid; (S)-(-)-α-methylbenzylamine hydrochloride; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 0.5h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 8h; Further stages.;

DOI:10.1021/jm7009414

Reference yield:

methanol (67-56-1) + (S)-4-(5-(methoxycarbamoyl)-2-methylphenylamino)-5-methyl-N-(1-phenylethyl)pyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (427877-76-7) → C25H25N5O3

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 16h;

DOI:10.1021/jm100540x

upstream raw materials:

4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

(S)-(-)-α-methylbenzylamine hydrochloride

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