Multi-step reaction with 12 steps
1.1: tetrahydrofuran; diethyl ether / 2 h / -5 - 0 °C
1.2: 0.5 h / 10 °C / pH 2.0
2.1: 5 h / 105 °C
3.1: ammonium acetate / ethanol / 7 h / 80 °C
4.1: hydrogenchloride; water / 12 h / 100 °C
5.1: hydrogenchloride / 96 h / Heating / reflux
6.1: pyridine / 8 h / 90 °C
6.2: -78 - 20 °C
7.1: trichlorophosphate / 18 h / Heating / reflux
8.1: tetrahydrofuran / 20 °C
9.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C
10.1: hydrogenchloride / diethyl ether; isopropyl alcohol / 80 °C
11.1: trichlorophosphate / 1 h / Heating / reflux
12.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / 50 °C
With
pyridine; hydrogenchloride; ammonium acetate; water; ammonium formate; caesium carbonate; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; isopropyl alcohol;
