GYKI 52895

Base Information

• Chemical Name: GYKI 52895
• CAS No.: 161832-73-1
• Molecular Formula: C₁₇H₁₇N₃O₂
• Molecular Weight: 295.341
• Mol file: 161832-73-1.mol

Synonyms:

Chemical Property of GYKI 52895

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GYKI 52895

There total 7 articles about GYKI 52895 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (102771-26-6) → GYKI 52895 (114460-08-1,161832-72-0,161832-73-1)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃; for 1h;

DOI:10.1081/SCC-120002397

Reference yield:

ethanol (64-17-5) + 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (102771-26-6) → GYKI 52895 (114460-08-1,161832-72-0,161832-73-1)

Guidance literature:

With pyridine; hydrogenchloride; sodium hydroxide; sodium borohydrid; In water;

Reference yield:

1-allyl-3,4-methylenedioxybenzene (94-59-7) → GYKI 52895 (114460-08-1,161832-72-0,161832-73-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Hg(OAc)2 / tetrahydrofuran / 1 h / 20 °C

1.2: 96 percent / NaBH₄; aq. NaOH / tetrahydrofuran / 1 h

2.1: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 °C

3.1: 60 percent / P₂O₅ / 1,2-dichloro-ethane / 8 h / 20 °C

4.1: 50 percent / hydrazine hydrate / ethanol / 2 h / 20 °C

5.1: 80 percent / SnCl₂ / ethanol / 1 h / 70 °C

6.1: 83 percent / NaBH₃CN; HCl / methanol / 1 h / 20 °C

With hydrogenchloride; mercury(II) diacetate; phosphorus pentoxide; sodium cyanoborohydride; hydrazine hydrate; pyridinium chlorochromate; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; 3.1: Friedel-Craft acylation;

DOI:10.1081/SCC-120002397

upstream raw materials:

1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine

1-allyl-3,4-methylenedioxybenzene

β-oxy-α-(3',4'-methylenedioxyphenyl)propane

1-(1,3-benzodioxol-5-yl)-2-propanone

Downstream raw materials:

talampanel

GYKI-53391