2-Pyrimidinamine, 4-[(5S)-2-(4-fluorophenyl)-6,7-dihydro-5-[[(4-methoxyphenyl)methoxy]methyl]-5H-pyrrolo[1,2-a]imidazol-3-yl]-N-propyl-

Base Information

Chemical Name:2-Pyrimidinamine, 4-[(5S)-2-(4-fluorophenyl)-6,7-dihydro-5-[[(4-methoxyphenyl)methoxy]methyl]-5H-pyrrolo[1,2-a]imidazol-3-yl]-N-propyl-
CAS No.:869287-23-0
Molecular Formula:C28H30FN5O2
Molecular Weight:487.577
Hs Code.:

Synonyms:4-[(5S)-2-(4-fluorophenyl)-5-[(4-methoxyphenyl)methoxymethyl]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-N-propylpyrimidin-2-amine;2-PyriMidinaMine, 4-[(5S)-2-(4-fluorophenyl)-6,7-dihydro-5-[[(4-Methoxyphenyl)Methoxy]Methyl]-5H-pyrrolo[1,2-a]iMidazol-3-yl]-N-propyl-

Suppliers and Price of 2-Pyrimidinamine, 4-[(5S)-2-(4-fluorophenyl)-6,7-dihydro-5-[[(4-methoxyphenyl)methoxy]methyl]-5H-pyrrolo[1,2-a]imidazol-3-yl]-N-propyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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American Custom Chemicals Corporation
4-[(5S)-2-(4-FLUOROPHENYL)-6,7-DIHYDRO-5-[[(4-METHOXYPHENYL)METHOXY]METHYL]-5H-PYRROLO-[1,2-A]IMIDAZO-2-PYRIMIDINAMINE 95.00%
5MG
$ 499.02

Total 1 raw suppliers

Chemical Property of 2-Pyrimidinamine, 4-[(5S)-2-(4-fluorophenyl)-6,7-dihydro-5-[[(4-methoxyphenyl)methoxy]methyl]-5H-pyrrolo[1,2-a]imidazol-3-yl]-N-propyl-

Chemical Property:

PSA：77.32000
LogP:5.10270

Purity/Quality:: 4-[(5S)-2-(4-FLUOROPHENYL)-6,7-DIHYDRO-5-[[(4-METHOXYPHENYL)METHOXY]METHYL]-5H-PYRROLO-[1,2-A]IMIDAZO-2-PYRIMIDINAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyrimidinamine, 4-[(5S)-2-(4-fluorophenyl)-6,7-dihydro-5-[[(4-methoxyphenyl)methoxy]methyl]-5H-pyrrolo[1,2-a]imidazol-3-yl]-N-propyl-

There total 13 articles about 2-Pyrimidinamine, 4-[(5S)-2-(4-fluorophenyl)-6,7-dihydro-5-[[(4-methoxyphenyl)methoxy]methyl]-5H-pyrrolo[1,2-a]imidazol-3-yl]-N-propyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 471844-88-9
2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

: 107-10-8,42939-71-9
propylamine

: 869287-23-0
{4-[2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine

Guidance literature:: 2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole; With dihydrogen peroxide; acetic acid; for 48h;

propylamine; at 20 ℃;
DOI:10.1016/j.bmcl.2005.07.076

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 869287-23-0
{4-[2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: imidazole / dimethylformamide / 2 h / 20 °C

2.1: Lawesson's reagent / tetrahydrofuran / 2 h / 20 °C

3.1: CH₂Cl₂ / 5 h / 20 °C

4.1: NH₄Cl / methanol / 3.5 h / 50 °C

5.1: ethyl acetate / 16 h / 20 °C

6.1: HBr; AcOH / aq. ethanol / 5.5 h / Heating

7.1: TBAF / tetrahydrofuran / 1 h / 0 - 20 °C

8.1: 99 percent / aq. NaOH; n-Bu₄NHSO₄ / 12 h / 20 °C

9.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

9.2: Bu₃SnI

9.3: 48 percent / Pd(PPh₃)4 / dimethylformamide / 96 h / 80 °C

10.1: H₂O₂; AcOH / 48 h

10.2: 36 percent / 20 °C

With Lawessons reagent; 1H-imidazole; sodium hydroxide; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen bromide; dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 9.3: Stille coupling;
DOI:10.1016/j.bmcl.2005.07.076

Reference yield:

: 852674-75-0
2-(tert-butyl-diphenyl-silanyloxymethyl)-5-methylsulfanyl-3,4-dihydro-2H-pyrrole

: 869287-23-0
{4-[2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: NH₄Cl / methanol / 3.5 h / 50 °C

2.1: ethyl acetate / 16 h / 20 °C

3.1: HBr; AcOH / aq. ethanol / 5.5 h / Heating

4.1: TBAF / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: 99 percent / aq. NaOH; n-Bu₄NHSO₄ / 12 h / 20 °C

6.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

6.2: Bu₃SnI

6.3: 48 percent / Pd(PPh₃)4 / dimethylformamide / 96 h / 80 °C

7.1: H₂O₂; AcOH / 48 h

7.2: 36 percent / 20 °C

With sodium hydroxide; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen bromide; dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; ethanol; ethyl acetate; 6.3: Stille coupling;
DOI:10.1016/j.bmcl.2005.07.076