ARRY-334543

Base Information

Chemical Name:ARRY-334543
CAS No.:845272-21-1
Molecular Formula:C22H19ClN6O2S
Molecular Weight:466.951
Hs Code.:
Mol file:845272-21-1.mol

Synonyms:ARRY334543; Varlitinib

Suppliers and Price of ARRY-334543

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Varlitinib
10mg
$ 370.00

TRC
Varlitinib
200mg
$ 2520.00

Medical Isotopes, Inc.
Varlitinib
5 mg
$ 750.00

Medical Isotopes, Inc.
Varlitinib
10 mg
$ 850.00

DC Chemicals
Varlitinib(ARRY-334543) >98%
1 g
$ 2700.00

Crysdot
Varlitinib 98+%
50mg
$ 567.00

Crysdot
Varlitinib 98+%
100mg
$ 770.00

Crysdot
Varlitinib 98+%
5mg
$ 126.00

Crysdot
Varlitinib 98+%
10mg
$ 196.00

ChemScene
Varlitinib ≥98.0%
10mg
$ 190.00

Total 27 raw suppliers

Chemical Property of ARRY-334543

Chemical Property:

Boiling Point:637.1±65.0 °C(Predicted)
PKA:6.54±0.70(Predicted)
PSA：121.79000
Density:1.51±0.1 g/cm3(Predicted)
LogP:4.83050

Purity/Quality:

97% ^*data from raw suppliers

Varlitinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Varlitinib is a tyrosine kinase inhibitor being developed for the treatment of cancer. Varlitinib acts by disrupting the receptor tyrosine kinases ErbB-2, ErbB-4 and EGFR.

Technology Process of ARRY-334543

There total 8 articles about ARRY-334543 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1012041-42-7
4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine

: C₄H₆ClNO

: 845272-21-1
Varlitinib

Guidance literature:: With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

: 851545-78-3
2-((2-chloro-4-nitrophenoxy)methyl)thiazole

: 845272-21-1
Varlitinib

Guidance literature:: Multi-step reaction with 4 steps

1: zinc; hydrogen / ethanol / 4 h

2: caesium carbonate / N,N-dimethyl-formamide / 100 °C

3: zinc; hydrogen / ethanol / 4 h

4: caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 100 °C

With copper(l) iodide; hydrogen; caesium carbonate; zinc; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 851545-79-4
3-chloro-4-(thiazol-2-ylmethoxy)aniline

: 845272-21-1
Varlitinib

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 100 °C

2: zinc; hydrogen / ethanol / 4 h

3: caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 100 °C

With copper(l) iodide; hydrogen; caesium carbonate; zinc; In ethanol; N,N-dimethyl-formamide;