3,4-Dihydro-6-Methoxy-7-(phenylMethoxy)-1-[[4-(phenylMethoxy)phenyl]Methyl]-isoquinoline

Base Information

Chemical Name:3,4-Dihydro-6-Methoxy-7-(phenylMethoxy)-1-[[4-(phenylMethoxy)phenyl]Methyl]-isoquinoline
CAS No.:500577-65-1
Molecular Formula:C₃₁H₂₉NO₃
Molecular Weight:463.576
Hs Code.:
Mol file:500577-65-1.mol

Synonyms:

Suppliers and Price of 3,4-Dihydro-6-Methoxy-7-(phenylMethoxy)-1-[[4-(phenylMethoxy)phenyl]Methyl]-isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,4-Dihydro-6-methoxy-7-(phenylmethoxy)-1-[[4-(phenylmethoxy)phenyl]methyl]-isoquinoline
100mg
$ 1320.00

Medical Isotopes, Inc.
3,4-Dihydro-6-methoxy-7-(phenylmethoxy)-1-[[4-(phenylmethoxy)phenyl]methyl]-isoquinoline
10 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of 3,4-Dihydro-6-Methoxy-7-(phenylMethoxy)-1-[[4-(phenylMethoxy)phenyl]Methyl]-isoquinoline

Chemical Property:

Solubility.:Chloroform, DCM, Methanol

Purity/Quality:: 3,4-Dihydro-6-methoxy-7-(phenylmethoxy)-1-[[4-(phenylmethoxy)phenyl]methyl]-isoquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3,4-Dihydro-6-methoxy-7-(phenylmethoxy)-1-[[4-(phenylmethoxy)phenyl]methyl]-isoquinoline is an intermediate in the synthesis of Coclaurine (C633550), a benzyltetrahydroisoquinoline alkaloid extracted from Magnolia salicifolia.

Technology Process of 3,4-Dihydro-6-Methoxy-7-(phenylMethoxy)-1-[[4-(phenylMethoxy)phenyl]Methyl]-isoquinoline

There total 9 articles about 3,4-Dihydro-6-Methoxy-7-(phenylMethoxy)-1-[[4-(phenylMethoxy)phenyl]Methyl]-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22231-61-4
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine

: 500577-65-1
1-(4-benzyloxybenzyl)-7-benzyloxy-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: CHCl₃; aqueous KOH

2: phosphoryl chloride; chloroform

With potassium hydroxide; chloroform; trichlorophosphate;
DOI:10.1007/BF02886324

Reference yield:

: 39188-62-0
2-(4-(benzyloxy)phenyl)acetyl chloride

: 500577-65-1
1-(4-benzyloxybenzyl)-7-benzyloxy-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: CHCl₃; aqueous KOH

2: phosphoryl chloride; chloroform

With potassium hydroxide; chloroform; trichlorophosphate;
DOI:10.1007/BF02886324

Reference yield:

: 100-39-0
benzyl bromide

: 500577-65-1
1-(4-benzyloxybenzyl)-7-benzyloxy-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

3: sodium carbonate / dichloromethane; water / 4 h / 20 °C

4: trichlorophosphate

With oxalyl dichloride; sodium carbonate; potassium carbonate; N,N-dimethyl-formamide; trichlorophosphate; In dichloromethane; water; 4: |Bischler-Napieralski Reaction;
DOI:10.1002/asia.201403361