Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-

Base Information

Chemical Name:Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-
CAS No.:1032314-85-4
Molecular Formula:C30H33N7O
Molecular Weight:507.638
Hs Code.:
Mol file:1032314-85-4.mol

Synonyms:Zhenghong Peng WBZ_4;

Suppliers and Price of Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-[4-METHYL-3-[[4-(6-METHYL-3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-4-[(4-METHYL-1-PIPERAZINYL)METHYL]BENZAMIDE 95.00%
5MG
$ 499.03

Total 4 raw suppliers

Chemical Property of Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-

Chemical Property:

PSA：86.28000
LogP:4.92050

Purity/Quality:

95% ^*data from raw suppliers

N-[4-METHYL-3-[[4-(6-METHYL-3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-4-[(4-METHYL-1-PIPERAZINYL)METHYL]BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-

There total 5 articles about Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1451042-78-6
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[(4-oxo-2-pyrimidinyl)amino]-phenyl]benzamide

: 659742-21-9
(6-methylpyridin-3-yl)boronic acid

: 1032314-85-4
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(6-methylpyridin-3-yl)-2-pyrimidinyl]amino]-phenyl]benzamide

Guidance literature:: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[(4-oxo-2-pyrimidinyl)amino]-phenyl]benzamide; With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; at 45 ℃; for 1.5h; Inert atmosphere;

(6-methylpyridin-3-yl)boronic acid; With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

With sodium carbonate; In 1,4-dioxane; water; for 24h; Inert atmosphere; Reflux;

Reference yield:

: 4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride

: 1032314-41-2
N-(2-methyl-5-aminophenyl)-4-(6-methyl-pyridyl)-2-pyrimidine-amine

: 1032314-85-4
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(6-methylpyridin-3-yl)-2-pyrimidinyl]amino]-phenyl]benzamide

Guidance literature:: With pyridine; at 20 ℃; for 18h;

Reference yield:

: 1025717-41-2
2-(2-methyl-5-nitrophenylamino)pyrimidin-4-one

: 1032314-85-4
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(6-methylpyridin-3-yl)-2-pyrimidinyl]amino]-phenyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; hydrogenchloride; iron / ethanol; water / 3.5 h / 55 - 65 °C

2.1: tetrahydrofuran / 24 h / 20 °C

3.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / 1,4-dioxane / 1.5 h / 45 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

3.3: 24 h / Inert atmosphere; Reflux

With hydrogenchloride; iron; ammonium chloride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; water;