3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

Base Information

Chemical Name:3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine
CAS No.:105852-50-4
Molecular Formula:C₂₁H₃₀INO₃
Molecular Weight:471.379
Hs Code.:

Synonyms:3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

Suppliers and Price of 3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

There total 3 articles about 3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 77-76-9
2,2-dimethoxy-propane

: 114469-37-3
((1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-iodo-propyl)-carbamic acid benzyl ester

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm00117a027

Reference yield:

: 114469-35-1
3-<(benzyloxycarbonyl)amino>-4-cyclohexyl-1-iodo-2-<(trimethylsilyl)oxy>-(2R,3S)-butane

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / KF, acetic acid / methanol / 4 h / Ambient temperature

2: 95 percent / p-toluenesulfonic acid / CH₂Cl₂ / 3 h / Ambient temperature

With potassium fluoride; toluene-4-sulfonic acid; acetic acid; In methanol; dichloromethane;
DOI:10.1021/jm00117a027

Reference yield:

: 1-<1-<(benzyloxycarbonyl)amino>-2-cyclohexyl-(1S)-ethyl>oxirane

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 65.7 g / NaI / acetonitrile / 0.67 h / 0 °C

2: 78 percent / KF, acetic acid / methanol / 4 h / Ambient temperature

3: 95 percent / p-toluenesulfonic acid / CH₂Cl₂ / 3 h / Ambient temperature

With potassium fluoride; toluene-4-sulfonic acid; acetic acid; sodium iodide; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00117a027