SKS-927

Base Information

• Chemical Name: SKS-927
• CAS No.: 885482-95-1
• Molecular Formula: C₂₇H₂₇Cl₂N₅O₂
• Molecular Weight: 524.45
• Mol file: 885482-95-1.mol

Synonyms:SKS-927;4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]quinoline-3-carbonitrile

Chemical Property of SKS-927

Chemical Property:

• PSA: 76.88000
• LogP: 4.46078

Purity/Quality:

SKS-927 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SKS-927

There total 7 articles about SKS-927 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxyquinolin-7-yl trifluoromethanesulfonate (364793-73-7) + 3-(N-methylpiperazino)-prop-1-yne (388121-83-3) → 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]-3-quinolinecarbonitrile (885482-95-1)

Guidance literature:

With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; methanol; at 60 ℃; for 4h; Product distribution / selectivity;

Reference yield: 37.0%

4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-hydroxy-but-1-ynyl)-6-methoxyquinoline-3-carbonitrile (885482-99-5) + 3-(N-methylpiperazino)-prop-1-yne (388121-83-3) → 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]-3-quinolinecarbonitrile (885482-95-1)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 4h; Product distribution / selectivity;

Reference yield: 25.0%

1-methyl-piperazine (109-01-3) + 4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-hydroxy-but-1-ynyl)-6-methoxyquinoline-3-carbonitrile (885482-99-5) → 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]-3-quinolinecarbonitrile (885482-95-1)

Guidance literature:

4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-hydroxy-but-1-ynyl)-6-methoxyquinoline-3-carbonitrile; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1.25h;

1-methyl-piperazine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; Product distribution / selectivity;

upstream raw materials:

1-methyl-piperazine

4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-iodo-6-methoxy-3-quinolinecarbonitrile

3-(N-methylpiperazino)-prop-1-yne

4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-hydroxy-but-1-ynyl)-6-methoxyquinoline-3-carbonitrile