(1'R,2R)-2-Benzyl-1-pyrrolidine

Base Information

Chemical Name:(1'R,2R)-2-Benzyl-1-pyrrolidine
CAS No.:135324-59-3
Molecular Formula:C₂₀H₂₆N₂O
Molecular Weight:310.439
Hs Code.:

(1'R,2R)-2-Benzyl-1-<N-(2-hydroxy-1-phenylethyl)-N-methylamino>pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'R,2R)-2-Benzyl-1-pyrrolidine

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Technology Process of (1'R,2R)-2-Benzyl-1-pyrrolidine

There total 10 articles about (1'R,2R)-2-Benzyl-1-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 135324-53-7
(1'R,2R)-2-Benzyl-1-pyrrolidine

: 74-88-4
methyl iodide

: 135324-59-3
(1'R,2R)-2-Benzyl-1-pyrrolidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1248/cpb.39.836

Reference yield:

: 1603-79-8
phenylglyoxylic acid ethyl ester

: 135324-59-3
(1'R,2R)-2-Benzyl-1-pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / 60 °C

2: 39 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

3: 69 percent / K₂CO₃ / dimethylformamide / Ambient temperature

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.836

Reference yield:

: 84773-28-4
(R)-2-(methylamino)-2-phenylethanol

: 135324-59-3
(1'R,2R)-2-Benzyl-1-pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: NaNO₂, HOAc / H₂O / 4 h / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 3 h / Heating

3: 1) MgSO₄, 2) K₂CO₃ / 1) CH₂Cl₂, 1h, rt, 2) benzene, 24 h, reflux

4: tetrahydrofuran / 12 h / 0 °C

With lithium aluminium tetrahydride; magnesium sulfate; potassium carbonate; acetic acid; sodium nitrite; In tetrahydrofuran; water;
DOI:10.1248/cpb.39.836