1H-Indole-5-carbonitrile, 2-((4-phenyl-1-piperazinyl)methyl)-

Base Information

Chemical Name:1H-Indole-5-carbonitrile, 2-((4-phenyl-1-piperazinyl)methyl)-
CAS No.:313972-96-2
Molecular Formula:C₂₀H₂₀N₄
Molecular Weight:316.406
Hs Code.:
UNII:YRL8JC6D3Z
Nikkaji Number:J1.446.201E
Wikidata:Q27294683
Pharos Ligand ID:QVUMPAZ9UALK
ChEMBL ID:CHEMBL140099

Synonyms:2-(4-phenylpiperazin-1-ylmethyl)indole-5-carbonitrile;FAUC 299;FAUC-299

Suppliers and Price of 1H-Indole-5-carbonitrile, 2-((4-phenyl-1-piperazinyl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole-5-carbonitrile, 2-((4-phenyl-1-piperazinyl)methyl)-

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:316.16879665
Heavy Atom Count:24
Complexity:456

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CC2=CC3=C(N2)C=CC(=C3)C#N)C4=CC=CC=C4

Technology Process of 1H-Indole-5-carbonitrile, 2-((4-phenyl-1-piperazinyl)methyl)-

There total 6 articles about 1H-Indole-5-carbonitrile, 2-((4-phenyl-1-piperazinyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 92-54-6
4-phenyl-1-piperazine

: 313972-70-2
2-chloromethylindole-5-carbonitrile

: 313972-96-2
FAUC 299

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1021/jm0009989

Reference yield:

: 92-54-6
4-phenyl-1-piperazine

: 313972-78-0
2-chloromethyl-1-diethoxymethylindole-5-carbonitrile

: 313972-96-2
FAUC 299

Guidance literature:: 2-chloromethyl-1-diethoxymethylindole-5-carbonitrile; With polymer-bound 3-benzyloxypropane-1,2-diol; toluene-4-sulfonic acid; In 1,4-dioxane; at 20 ℃; for 3h;

4-phenyl-1-piperazine; In N,N-dimethyl-formamide; at 40 ℃; for 48h;

With hydrogenchloride; In 1,4-dioxane; at 40 ℃; for 3h; Further stages.;
DOI:10.1021/jm0009989

Reference yield:

: 104291-67-0
2-(hydroxymethyl)indole-5-carbonitrile

: 313972-96-2
FAUC 299

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / CCl₄; PPh₃ / dimethylformamide / 16 h / 20 °C

2: 90 percent / dimethylformamide / 2 h / 60 °C

With tetrachloromethane; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1021/jm0009989