1H-Indazole-6-carboxylic acid, 7-hydroxy-

Base Information

• Chemical Name: 1H-Indazole-6-carboxylic acid, 7-hydroxy-
• CAS No.: 907190-32-3
• Molecular Formula: C8H6N2O3
• Molecular Weight: 178.14
• Mol file: 907190-32-3.mol

Synonyms:7-Hydroxy-1H-indazol-6-carboxylic acid;7-hydroxy-1H-Indazole-6-carboxylic acid;1H-Indazole-6-carboxylic acid, 7-hydroxy-

Chemical Property of 1H-Indazole-6-carboxylic acid, 7-hydroxy-

Chemical Property:

• PSA: 86.21000
• LogP: 0.96670

Purity/Quality:

NLT 98% ^*data from raw suppliers

7-Hydroxy-1H-indazole-6-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole-6-carboxylic acid, 7-hydroxy-

There total 5 articles about 1H-Indazole-6-carboxylic acid, 7-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7-methoxyindazole-6-carboxylic acid methyl ester (907190-29-8) → 7-hydroxyindazole-6-carboxylic acid (907190-32-3)

Guidance literature:

With hydrogen bromide; at 80 ℃; for 18h;

DOI:10.1021/jm060408s

Reference yield:

5-chloro-2-methoxy-4-methyl-3-nitrobenzoic acid methyl ester (907190-25-4) → 7-hydroxyindazole-6-carboxylic acid (907190-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / Et₃N; H₂ / Pd(OH)2/C / ethanol / 8 h / 20 °C / 2585.74 Torr

2: 74 percent / i-amylnitrite; AcOH / 1.5 h

3: 96 percent / aq. HBr / 18 h / 80 °C

With hydrogen bromide; hydrogen; acetic acid; triethylamine; isopentyl nitrite; palladium dihydroxide; In ethanol;

DOI:10.1021/jm060408s

Reference yield:

methyl 4-methyl-2-methoxybenzoate (81245-24-1) → 7-hydroxyindazole-6-carboxylic acid (907190-32-3)

Guidance literature:

Multi-step reaction with 5 steps

1: NCS / dimethylformamide / 72 h / 20 °C

2: 18.45 g / HNO₃; AcOH; Ac₂O / 18 h / 20 °C

3: 98 percent / Et₃N; H₂ / Pd(OH)2/C / ethanol / 8 h / 20 °C / 2585.74 Torr

4: 74 percent / i-amylnitrite; AcOH / 1.5 h

5: 96 percent / aq. HBr / 18 h / 80 °C

With N-chloro-succinimide; hydrogen bromide; hydrogen; nitric acid; acetic anhydride; acetic acid; triethylamine; isopentyl nitrite; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm060408s

upstream raw materials:

7-methoxyindazole-6-carboxylic acid methyl ester

3-amino-2-methoxy-4-methylbenzoic acid methyl ester

5-chloro-2-methoxy-4-methyl-3-nitrobenzoic acid methyl ester

methyl 4-methyl-2-methoxybenzoate

Refernces