Methyl 3-aMino-2-Methoxy-4-Methylbenzoate

Base Information

• Chemical Name: Methyl 3-aMino-2-Methoxy-4-Methylbenzoate
• CAS No.: 907190-26-5
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2922509090
• Mol file: 907190-26-5.mol

Synonyms:Benzoic acid,3-amino-2-methoxy-4-methyl-,methyl ester;3-amino-2-methoxy-4-methylbenzoic acid methyl ester;

Chemical Property of Methyl 3-aMino-2-Methoxy-4-Methylbenzoate

Chemical Property:

• PSA: 61.55000
• LogP: 1.95360
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

Methyl3-amino-2-methoxy-4-methylbenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 3-aMino-2-Methoxy-4-Methylbenzoate

There total 3 articles about Methyl 3-aMino-2-Methoxy-4-Methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-chloro-2-methoxy-4-methyl-3-nitrobenzoic acid methyl ester (907190-25-4) → 3-amino-2-methoxy-4-methylbenzoic acid methyl ester (907190-26-5)

Guidance literature:

With hydrogen; triethylamine; palladium dihydroxide; In ethanol; at 20 ℃; for 8h; under 2585.74 Torr;

DOI:10.1021/jm060408s

Reference yield:

methyl 4-methyl-2-methoxybenzoate (81245-24-1) → 3-amino-2-methoxy-4-methylbenzoic acid methyl ester (907190-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NCS / dimethylformamide / 72 h / 20 °C

2: 18.45 g / HNO₃; AcOH; Ac₂O / 18 h / 20 °C

3: 98 percent / Et₃N; H₂ / Pd(OH)2/C / ethanol / 8 h / 20 °C / 2585.74 Torr

With N-chloro-succinimide; hydrogen; nitric acid; acetic anhydride; acetic acid; triethylamine; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm060408s

Reference yield:

5-chloro-2-methoxy-4-methyl-benzoic acid methyl ester (907190-23-2) → 3-amino-2-methoxy-4-methylbenzoic acid methyl ester (907190-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 18.45 g / HNO₃; AcOH; Ac₂O / 18 h / 20 °C

2: 98 percent / Et₃N; H₂ / Pd(OH)2/C / ethanol / 8 h / 20 °C / 2585.74 Torr

With hydrogen; nitric acid; acetic anhydride; acetic acid; triethylamine; palladium dihydroxide; In ethanol;

DOI:10.1021/jm060408s

upstream raw materials:

5-chloro-2-methoxy-4-methyl-3-nitrobenzoic acid methyl ester

methyl 4-methyl-2-methoxybenzoate

5-chloro-2-methoxy-4-methyl-benzoic acid methyl ester

Downstream raw materials:

7-hydroxyindazole-6-carboxylic acid

7-methoxyindazole-6-carboxylic acid methyl ester

Refernces