N,N-Dimethyl-2-amino-2-methylpropanamide

Base Information

• Chemical Name: N,N-Dimethyl-2-amino-2-methylpropanamide
• CAS No.: 62983-26-0
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.19
• Hs Code.: 2924199090
• Mol file: 62983-26-0.mol

Synonyms:N,N-Dimethyl-2-amino-2-methylpropanamide;2-Amino-N,N,2-trimethylpropanamide;

Chemical Property of N,N-Dimethyl-2-amino-2-methylpropanamide

Chemical Property:

• Boiling Point: 194.708 °C at 760 mmHg
• Flash Point: 71.557 °C
• PSA: 46.33000
• Density: 0.96 g/cm³
• LogP: 0.51220

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-N,N,2-trimethyl-propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-N,N,2-trimethyl-propanamide is used in preparation of fused heteroarylpyridine amines as large tumor suppressor kinase inhibitors.

Technology Process of N,N-Dimethyl-2-amino-2-methylpropanamide

There total 9 articles about N,N-Dimethyl-2-amino-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Gemonil (50-11-3) + isopropyl alcohol (67-63-0,8013-70-5) → 2-Amino-N',N'-dimethylisobutyramid (62983-26-0) + 5,5-Diethyl-1-isopropyl-3-methylbarbitursaeure (132660-11-8)

Guidance literature:

With morpholine; 3-dimethylamino-2,2-dimethyl-2H-azirine; for 84h; Heating;

DOI:10.1002/hlca.19900730824

Reference yield: 88.0%

methanol (67-56-1) + Gemonil (50-11-3) → N,N'-dimethylbarbital (714-59-0) + 2-Amino-N',N'-dimethylisobutyramid (62983-26-0)

Guidance literature:

With morpholine; 3-dimethylamino-2,2-dimethyl-2H-azirine; Heating; 1) 1 d, 2) 2 d, 3) 6 d;

DOI:10.1002/hlca.19900730824

Reference yield: 85.0%

Gemonil (50-11-3) + benzyl alcohol (100-51-6,185532-71-2) → 2-Amino-N',N'-dimethylisobutyramid (62983-26-0) + 1-Benzyl-5,5-diethyl-3-methylbarbitursaeure (132660-15-2)

Guidance literature:

With morpholine; 3-dimethylamino-2,2-dimethyl-2H-azirine; for 240h; Heating;

DOI:10.1002/hlca.19900730824

upstream raw materials:

methanol

Gemonil

(S)-2-butanol

d⁽⁴⁾-methanol

Downstream raw materials:

1-dimethylamino-2-methyl-2-aminopropane

N,N-Dimethyl-2-(p-tolylsulfonylamino)isobutyramid

Refernces

• 1、 Schlaepfer-Daehler, Marlise,Heimgartner, Heinz. "Reactions of 3-(Dimethylamino)-2,2-dimethyl-2H-azirines with Barbituric-Acid Derivatives". . p. 2275 - 2286. Retrieved 2007/10/02.