7-Chlorokynurenic acid

Base Information

Chemical Name:7-Chlorokynurenic acid
CAS No.:18000-24-3
Molecular Formula:C10H6ClNO3
Molecular Weight:223.616
Hs Code.:2933499090
European Community (EC) Number:241-913-6
NSC Number:149792
UNII:S7936QON2K
DSSTox Substance ID:DTXSID7042568
Nikkaji Number:J377.342F,J260.823E
Wikipedia:7-Chlorokynurenic_acid
Wikidata:Q15634175
Metabolomics Workbench ID:63073
ChEMBL ID:CHEMBL311389
Mol file:18000-24-3.mol

Synonyms:7-chlorokynurenate;7-chlorokynurenic acid

Suppliers and Price of 7-Chlorokynurenic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
7-Chlorokynurenic acid
10mg
$ 325.00

TRC
7-Chlorokynurenicacid
25mg
$ 160.00

Tocris
7-Chlorokynurenicacid ≥98%(HPLC)
10
$ 86.00

Tocris
7-Chlorokynurenicacid ≥98%(HPLC)
50
$ 360.00

Crysdot
7-Chloro-4-hydroxyquinoline-2-carboxylicacidhydrochloride 95+%
5g
$ 740.00

Crysdot
7-Chloro-4-hydroxyquinoline-2-carboxylicacidhydrochloride 95+%
1g
$ 322.00

ChemScene
7-Chlorokynurenicacid 99.71%
50mg
$ 290.00

ChemScene
7-Chlorokynurenicacid 99.71%
10mg
$ 70.00

ChemScene
7-Chlorokynurenicacid 99.71%
100mg
$ 520.00

Chemenu
7-chloro-4-hydroxyquinoline-2-carboxylicacidhydrochloride 95%
1g
$ 371.00

Total 17 raw suppliers

Chemical Property of 7-Chlorokynurenic acid

Chemical Property:

Appearance/Colour:White to yellowish powder
Vapor Pressure:6E-07mmHg at 25°C
Melting Point:277-278 °C (decomp)
Refractive Index:1.648
Boiling Point:395 °C at 760 mmHg
PKA:0.90±0.30(Predicted)
Flash Point:192.7 °C
PSA：70.42000
Density:1.549 g/cm³
LogP:2.29200
Storage Temp.:Store at RT
Solubility.:0.1 M NaOH: 13.7 mg/mL
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:223.0036207
Heavy Atom Count:15
Complexity:340

Purity/Quality:

98% ^*data from raw suppliers

7-Chlorokynurenic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1Cl)NC(=CC2=O)C(=O)O
Uses NMDA receptor antagonist at the glycine site
Biological Functions Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.

Technology Process of 7-Chlorokynurenic acid

There total 3 articles about 7-Chlorokynurenic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21640-97-1
7-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

: 18000-24-3
7-chlorokynurenic acid

Guidance literature:: With sodium hydroxide;
DOI:10.1021/ja01205a036

Reference yield:

: 108-42-9
3-chloro-aniline

: 18000-24-3
7-chlorokynurenic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / Erhitzen des Reaktionsprodukts in Paraffinoel auf 250grad

2: aqueous NaOH

With sodium hydroxide; acetic acid;
DOI:10.1021/ja01205a036