Technology Process of Acetic acid (1S,2R,3R,5S)-2,3-diacetoxy-4-methylene-5-phenylacetylamino-cyclopentyl ester
There total 6 articles about Acetic acid (1S,2R,3R,5S)-2,3-diacetoxy-4-methylene-5-phenylacetylamino-cyclopentyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-Bu4NIO4, 2.) Na/Hg / 1.) MeOH, -20 deg C, 24 h, 2.) THF, MeOH, 0 deg C, 8 h
2: 100 percent / DMAP / pyridine / 20 h
3: 1.) N-methylmorpholine N-oxide, OsO4, 2.) DMAP / 1.) Me2CO, H2O, room temperature, 48 h, 2.) pyridine, room temperature, 24 h
4: 100 percent / H2 / Pd/C / ethanol / 8 h / Ambient temperature
5: 1.) o-O2NC6H4SeCN, n-Bu3P, 2.) 30percent H2O2 / 1.) THF, room temperature, 4 h, 2.) room temperature, 5 h
With
dmap; sodium amalgam; osmium(VIII) oxide; ortho-nitrophenyl selenocyanate; tributylphosphine; hydrogen; dihydrogen peroxide; tetrabutylammonium periodite; 4-methylmorpholine N-oxide;
palladium on activated charcoal;
In
pyridine; ethanol;
DOI:10.1021/jo980050a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-Bu4NIO4, 2.) Na/Hg / 1.) MeOH, -20 deg C, 24 h, 2.) THF, MeOH, 0 deg C, 8 h
2: 100 percent / DMAP / pyridine / 20 h
3: 1.) N-methylmorpholine N-oxide, OsO4, 2.) DMAP / 1.) Me2CO, H2O, room temperature, 48 h, 2.) pyridine, room temperature, 24 h
4: 100 percent / H2 / Pd/C / ethanol / 8 h / Ambient temperature
5: 1.) o-O2NC6H4SeCN, n-Bu3P, 2.) 30percent H2O2 / 1.) THF, room temperature, 4 h, 2.) room temperature, 5 h
With
dmap; sodium amalgam; osmium(VIII) oxide; ortho-nitrophenyl selenocyanate; tributylphosphine; hydrogen; dihydrogen peroxide; tetrabutylammonium periodite; 4-methylmorpholine N-oxide;
palladium on activated charcoal;
In
pyridine; ethanol;
DOI:10.1021/jo980050a
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) N-methylmorpholine N-oxide, OsO4, 2.) DMAP / 1.) Me2CO, H2O, room temperature, 48 h, 2.) pyridine, room temperature, 24 h
2: 100 percent / H2 / Pd/C / ethanol / 8 h / Ambient temperature
3: 1.) o-O2NC6H4SeCN, n-Bu3P, 2.) 30percent H2O2 / 1.) THF, room temperature, 4 h, 2.) room temperature, 5 h
With
dmap; osmium(VIII) oxide; ortho-nitrophenyl selenocyanate; tributylphosphine; hydrogen; dihydrogen peroxide; 4-methylmorpholine N-oxide;
palladium on activated charcoal;
In
ethanol;
DOI:10.1021/jo980050a
