Anacetrapib

Base Information

Chemical Name:Anacetrapib
CAS No.:875446-37-0
Molecular Formula:C30H25F10NO3
Molecular Weight:637.517
Hs Code.:
European Community (EC) Number:810-468-5
UNII:P7T269PR6S
ChEMBL ID:CHEMBL1800807
DSSTox Substance ID:DTXSID90236452
Metabolomics Workbench ID:149870
NCI Thesaurus Code:C75251
Nikkaji Number:J2.620.043A
Pharos Ligand ID:U4RN9W5YMRGL
Wikidata:Q4750639
Wikipedia:Anacetrapib
Mol file:875446-37-0.mol

Synonyms:anacetrapib;MK 0859;MK-0859;MK0859

Suppliers and Price of Anacetrapib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Anacetrapib
25mg
$ 6720.00

Matrix Scientific
(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)-4-methyl-1,3-oxazolidin-2-one
1g
$ 720.00

Labseeker
Anacetrapib 95
1g
$ 1010.00

DC Chemicals
Anacetrapib(MK0859) >98%
1 g
$ 1200.00

DC Chemicals
Anacetrapib(MK0859) >98%
100 mg
$ 350.00

Crysdot
Anacetrapib 98+%
25mg
$ 513.00

Crysdot
Anacetrapib 98+%
10mg
$ 256.00

Crysdot
Anacetrapib 98+%
50mg
$ 973.00

ChemScene
Anacetrapib 99.62%
100mg
$ 880.00

ChemScene
Anacetrapib 99.62%
10mg
$ 200.00

Total 118 raw suppliers

Chemical Property of Anacetrapib

Chemical Property:

Boiling Point:555.309 °C at 760 mmHg
PKA:-2.30±0.60(Predicted)
Flash Point:289.641 °C
PSA：38.77000
Density:1.345 g/cm³
LogP:9.70100
Solubility.:≥31.9 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH
XLogP3:8.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:6
Exact Mass:637.16747528
Heavy Atom Count:44
Complexity:964

Purity/Quality:

99%, ^*data from raw suppliers

Anacetrapib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F
Isomeric SMILES:C[C@H]1[C@H](OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F
Recent ClinicalTrials:The Effect of Anacetrapib on Vascular Function and Arterial Stiffness
Recent EU Clinical Trials:A Worldwide, Multicenter, Double-Blind, Randomized, Placebo-Controlled, 12-Week Study to Assess the Efficacy and Tolerability of Anacetrapib When Added to Ongoing Lipid-Lowering Therapy in Adult Patients with Homozygous Familial Hypercholesterolemia (HoFH) with a 52-Week Open-Label Extension
Uses An orally active and potent cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia.

Technology Process of Anacetrapib

There total 42 articles about Anacetrapib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 875551-28-3
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl

: 875444-08-9
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

: 875446-37-0
anacetrapib

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 17h;

Reference yield: 89.0%

: C₃₇H₃₃F₁₀NO₄

: 875446-37-0
anacetrapib

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;

Reference yield: 88.0%

: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

: 875551-28-3
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl

: 875446-37-0
anacetrapib

Guidance literature:: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one; With sodium hexamethyldisilazane; In N,N-dimethyl-formamide; at -15 ℃; for 1.5h;

2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl; In N,N-dimethyl-formamide; at -15 - 12 ℃;