2-ACETYL-7-HYDROXYBENZOFURAN

Base Information

• Chemical Name: 2-ACETYL-7-HYDROXYBENZOFURAN
• CAS No.: 40020-87-9
• Molecular Formula: C10H8O3
• Molecular Weight: 176.172
• Hs Code.: 2932999099
• Mol file: 40020-87-9.mol

Synonyms:2-ACETYL-7-HYDROXYBENZOFURAN;2-ACETYL-7-HYDROXYCOUMARONE;2-Acetyl-7-hydroxybenzofurane;2-ACETYL-7-HYDROXYBENZOFURAN 97+%;2-Acetylbenzofuran-7-ol

Chemical Property of 2-ACETYL-7-HYDROXYBENZOFURAN

Chemical Property:

• Vapor Pressure: 0.000103mmHg at 25°C
• Melting Point: 166°C
• Boiling Point: 327.8°C at 760 mmHg
• Flash Point: 152°C
• PSA: 50.44000
• Density: 1.292g/cm³
• LogP: 2.34100

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Acetyl-7-hydroxybenzofuran ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Acetyl-7-hydroxybenzofuran is a reagent used to synthesize Befunolol (B131100).

Technology Process of 2-ACETYL-7-HYDROXYBENZOFURAN

There total 3 articles about 2-ACETYL-7-HYDROXYBENZOFURAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-Acetyl-7-methoxybenzofuran (43071-52-9) → 2-acetyl-7-hydroxybenzofuran (40020-87-9)

Guidance literature:

With aluminium trichloride; In xylene; for 3h; Heating;

Reference yield:

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 2-acetyl-7-hydroxybenzofuran (40020-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / K₂CO₃ / acetone

2: 57 percent / AlCl₃ / xylene / 3 h / Heating

With aluminium trichloride; potassium carbonate; In acetone; xylene;

Reference yield:

→ 2-acetyl-7-hydroxybenzofuran (40020-87-9)

Guidance literature:

7-Methoxy-2-acetyl-cumaron, Pyridinhydrochlorid (Demethylierg.);

upstream raw materials:

2-Acetyl-7-methoxybenzofuran

3-methoxy-2-hydroxybenzaldehyde

Downstream raw materials:

2-acetyl-7-ethoxybenzofuran

2-Acetyl-7-p-nitrobenzyloxybenzofuran

1-[4-bromo-7-(1-phenylethoxy)benzofuran-2-yl]ethanone

1-(7-benzhydryloxy-4-bromo-benzofuran-2-yl)-ethanone

Refernces