(S)-2-methylpiperidine hydrochloride

Base Information

• Chemical Name: (S)-2-methylpiperidine hydrochloride
• CAS No.: 205526-61-0
• Molecular Formula: C₆H₁₃N*ClH
• Molecular Weight: 135.637
• Hs Code.: 2933399990
• Mol file: 205526-61-0.mol

Synonyms:

Chemical Property of (S)-2-methylpiperidine hydrochloride

Chemical Property:

• Melting Point: 195-197 °C

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-Methylpiperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-methylpiperidine hydrochloride

There total 18 articles about (S)-2-methylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-methyl-2,3,4,5-tetrahydro-pyridine (1462-92-6) → 2-methylpiperidine hydrochloride (5119-88-0,205526-61-0)

Guidance literature:

6-methyl-2,3,4,5-tetrahydro-pyridine; With methanol; sodium cyanoborohydride; zinc(II) chloride;

With hydrogenchloride; In water;

DOI:10.1002/adsc.200900302

Reference yield: 98.0%

1-[(S)-((R)-2-Methyl-piperidin-1-yl)-phenyl-methyl]-naphthalen-2-ol (667870-56-6) → (+)-(2R)-2-methylpiperidine hydrochloride (5119-88-0,205526-61-0)

Guidance literature:

With dichloromethane; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 48h; atmospheric pressure;

DOI:10.1021/jo0480444

Reference yield: 93.0%

(S)-4-isopropyl-3-(6-methylpyridin-2-yl)oxazolidin-2-one (737760-86-0) → (4S)-4-isopropyl-1,3-oxazolidin-2-one (17016-83-0) + (S)-2-methylpiperidine hydrochloride (5119-88-0,205526-61-0)

Guidance literature:

(S)-4-isopropyl-3-(6-methylpyridin-2-yl)oxazolidin-2-one; With hydrogen; acetic acid; 20% palladium hydroxide on carbon; at 50 ℃; for 22h; under 75007.5 Torr;

With hydrogenchloride; In methanol; water; Product distribution / selectivity;

upstream raw materials:

B(OC₂H₅)2(CH₂)4CH(N₃)CH₃

B(OH)2(CH₂)4CHBrCH₃

boron trichloride

6-methyl-2,3,4,5-tetrahydro-pyridine

Downstream raw materials:

3-(2-methyl-piperidino)-1-(4-propoxy-phenyl)-propan-1-one

(2R)-methylpiperidine

(2-methylpiperidin-1-yl)(phenyl)methanone

1-(4-methoxy-phenyl)-3-(2-methyl-piperidino)-propan-1-one; hydrochloride