6-methyl-2,3,4,5-tetrahydropyridine

Base Information

• Chemical Name: 6-methyl-2,3,4,5-tetrahydropyridine
• CAS No.: 1462-92-6
• Molecular Formula: C6H11 N
• Molecular Weight: 97.16
• Mol file: 1462-92-6.mol

Synonyms:2-Picoline,3,4,5,6-tetrahydro- (6CI,7CI,8CI); 2,3,4,5-Tetrahydro-6-methylpyridine;2-Methyl-1,2-dehydropiperidine; 2-Methyl-3,4,5,6-tetrahydropyridine;3,4,5,6-Tetrahydro-2-methylpyridine

Chemical Property of 6-methyl-2,3,4,5-tetrahydropyridine

Chemical Property:

• Vapor Pressure: 16.5mmHg at 25°C
• Boiling Point: 122.8°C at 760 mmHg
• PKA: 8.06±0.20(Predicted)
• Flash Point: 19°C
• PSA: 12.36000
• Density: 0.93g/cm³
• LogP: 1.06680

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-methyl-2,3,4,5-tetrahydropyridine

There total 8 articles about 6-methyl-2,3,4,5-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

hexa-4,5-dien-1-amine (166303-35-1) → 6-methyl-2,3,4,5-tetrahydro-pyridine (1462-92-6) + 2-vinylpyrrolidine (107131-61-3)

Guidance literature:

With dimethyltitanocene; at 135 ℃; for 3h;

DOI:10.1021/ol0256724

Reference yield:

2-Methylpiperidin (109-05-7,3000-79-1) → 6-methyl-2,3,4,5-tetrahydro-pyridine (1462-92-6) + 1-Methyl-pentylamin (68107-05-1) + trans-2-hexene (4050-45-7) + hexane (110-54-3)

Guidance literature:

With Dimethyldisulphide; hydrogen; nickel phosphide; silica gel; In various solvent(s); at 329.85 ℃; under 23251.9 Torr; Further Variations:; Catalysts; sitetime; Product distribution;

DOI:10.1021/jp0491941

Reference yield:

α-picoline (109-06-8) → 6-methyl-2,3,4,5-tetrahydro-pyridine (1462-92-6) + 1-Methyl-pentylamin (68107-05-1) + hexan-1-amine (111-26-2) + 2-Methylpiperidin (109-05-7,3000-79-1)

Guidance literature:

With dibenzothiophene; hydrogen sulfide; hydrogen; nickel molybdenum; at 300 ℃; Further Variations:; Temperatures; partial pressure of H2S; Product distribution;

DOI:10.1016/S0021-9517(03)00264-1

upstream raw materials:

2,3,4,5-tetrahydro-6-methoxypyridine

methyl magnesium iodide

dibutyl ether

1-aminohex-trans-4-ene

Downstream raw materials:

2-Methylpiperidin

N-(5-oxohexyl)benzamide

α-picoline

1-(2'-iodobenzoyl)-2-methyl-1,4,5,6-tetrahydropyridine