{(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol

Base Information

Chemical Name:{(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol
CAS No.:204447-36-9
Molecular Formula:C₄₃H₆₈O₆Si
Molecular Weight:709.095
Hs Code.:

Synonyms:

Suppliers and Price of {(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol

There total 13 articles about {(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146916-76-9
5-(4-methoxyphenyl)methoxy-2-pentyn-1-ol

: 204447-36-9
{(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) Red-Al; 2.) I₂ / 1.) Et₂O, 0 deg C to 25 deg C; 2.) Et₂O, -50 deg C to 25 deg C

2: PPTS / CH₂Cl₂

3: 1.) t-BuLi / 1.) Et₂O, -78 deg C; 2.) DMF

4: DIBAH / CH₂Cl₂ / -78 °C

5: NaH, n-Bu₄NI / tetrahydrofuran / Heating

6: PPTS / methanol / Heating

7: diisopropyl L-tartrate, Ti(O-i-Pr)4, t-BuOOH, 4 Angstroem molecular sieves / CH₂Cl₂ / -30 °C

8: CuI / tetrahydrofuran / -25 °C

9: PPTS / benzene / Heating

10: 1.) OsO₄, NMO; 2.) NaIO₄ / 1.) THF, H₂O; 2.) THF, H₂O

11: 80 percent / n-BuLi / tetrahydrofuran / 0 °C

12: Li / tetrahydrofuran; liquid ammonia / -33 °C

13: Et₃N / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; copper(l) iodide; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; L-(+)-diisopropyl tartrate; 4 A molecular sieve; iodine; tert.-butyl lithium; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; lithium; sodium hydride; diisobutylaluminium hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; dichloromethane; ammonia; benzene;
DOI:10.1016/S0040-4039(97)10754-7

Reference yield:

: 409064-76-2
(Z)-3-Iodo-5-(4-methoxy-benzyloxy)-pent-2-en-1-ol

: 204447-36-9
{(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol

Guidance literature:: Multi-step reaction with 12 steps

1: PPTS / CH₂Cl₂

2: 1.) t-BuLi / 1.) Et₂O, -78 deg C; 2.) DMF

3: DIBAH / CH₂Cl₂ / -78 °C

4: NaH, n-Bu₄NI / tetrahydrofuran / Heating

5: PPTS / methanol / Heating

6: diisopropyl L-tartrate, Ti(O-i-Pr)4, t-BuOOH, 4 Angstroem molecular sieves / CH₂Cl₂ / -30 °C

7: CuI / tetrahydrofuran / -25 °C

8: PPTS / benzene / Heating

9: 1.) OsO₄, NMO; 2.) NaIO₄ / 1.) THF, H₂O; 2.) THF, H₂O

10: 80 percent / n-BuLi / tetrahydrofuran / 0 °C

11: Li / tetrahydrofuran; liquid ammonia / -33 °C

12: Et₃N / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; copper(l) iodide; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; L-(+)-diisopropyl tartrate; 4 A molecular sieve; tert.-butyl lithium; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; lithium; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; ammonia; benzene;
DOI:10.1016/S0040-4039(97)10754-7

Reference yield:

: 204447-27-8
2-[(Z)-3-Iodo-5-(4-methoxy-benzyloxy)-pent-2-enyloxy]-tetrahydro-pyran

: 204447-36-9
{(4R,5R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-[(Z)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-methanol

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) t-BuLi / 1.) Et₂O, -78 deg C; 2.) DMF

2: DIBAH / CH₂Cl₂ / -78 °C

3: NaH, n-Bu₄NI / tetrahydrofuran / Heating

4: PPTS / methanol / Heating

5: diisopropyl L-tartrate, Ti(O-i-Pr)4, t-BuOOH, 4 Angstroem molecular sieves / CH₂Cl₂ / -30 °C

6: CuI / tetrahydrofuran / -25 °C

7: PPTS / benzene / Heating

8: 1.) OsO₄, NMO; 2.) NaIO₄ / 1.) THF, H₂O; 2.) THF, H₂O

9: 80 percent / n-BuLi / tetrahydrofuran / 0 °C

10: Li / tetrahydrofuran; liquid ammonia / -33 °C

11: Et₃N / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; copper(l) iodide; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; L-(+)-diisopropyl tartrate; 4 A molecular sieve; tert.-butyl lithium; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; lithium; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; ammonia; benzene;
DOI:10.1016/S0040-4039(97)10754-7