Technology Process of (1S,5S)-3-Hydroxymethyl-5-methoxy-2,2,4-trimethyl-cyclohex-3-enecarbaldehyde
There total 14 articles about (1S,5S)-3-Hydroxymethyl-5-methoxy-2,2,4-trimethyl-cyclohex-3-enecarbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
methanol;
for 0.5h;
Ambient temperature;
DOI:10.1248/cpb.32.1294
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 2.11 g / 10 percent KOH / methanol / 1.5 h / Ambient temperature
2: 97 percent / p-toluenesulfonic acid monohydrate / CH2Cl2 / 0.5 h
3: 42 percent / 80 percent m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature
4: 82 percent / sodium tertiary amylate / tetrahydrofuran; dimethylsulfoxide / 0.05 h / 70 °C
5: 92 percent / Na, liq. NH3 / tetrahydrofuran / 0.5 h / -78 °C
6: 635 mg / pyridine / Ambient temperature
7: 92 percent / selenium dioxide / dioxane; pyridine / 2.5 h / 80 °C
8: 95 percent / silver oxide / dimethylformamide / 24 h / Ambient temperature
9: 96 percent / p-toluenesulfonic acid monohydrate / aq. ethanol / 1.5 h / Ambient temperature
10: 100 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature
11: 62 percent / 10 percent NaOMe / methanol / 0.5 h / Ambient temperature
With
potassium hydroxide; selenium(IV) oxide; ammonia; sodium methylate; sodium; sodium tert-pentoxide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; silver(l) oxide;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.32.1294
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 97 percent / p-toluenesulfonic acid monohydrate / CH2Cl2 / 0.5 h
2: 42 percent / 80 percent m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature
3: 82 percent / sodium tertiary amylate / tetrahydrofuran; dimethylsulfoxide / 0.05 h / 70 °C
4: 92 percent / Na, liq. NH3 / tetrahydrofuran / 0.5 h / -78 °C
5: 635 mg / pyridine / Ambient temperature
6: 92 percent / selenium dioxide / dioxane; pyridine / 2.5 h / 80 °C
7: 95 percent / silver oxide / dimethylformamide / 24 h / Ambient temperature
8: 96 percent / p-toluenesulfonic acid monohydrate / aq. ethanol / 1.5 h / Ambient temperature
9: 100 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature
10: 62 percent / 10 percent NaOMe / methanol / 0.5 h / Ambient temperature
With
selenium(IV) oxide; ammonia; sodium methylate; sodium; sodium tert-pentoxide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; silver(l) oxide;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.32.1294
