2-(4-Dimethylaminophenyl)furan

Base Information

• Chemical Name: 2-(4-Dimethylaminophenyl)furan
• CAS No.: 100191-85-3
• Molecular Formula: C12H13NO
• Molecular Weight: 187.241
• Mol file: 100191-85-3.mol

Synonyms:Benzenamine,4-(2-furanyl)-N,N-dimethyl;2-(4-Dimethylaminophenyl)furan;

Chemical Property of 2-(4-Dimethylaminophenyl)furan

Chemical Property:

• PSA: 16.38000
• LogP: 3.01260

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Dimethylaminophenyl)furan

There total 5 articles about 2-(4-Dimethylaminophenyl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

propargyl p-toluenesulfonate (6165-76-0) → 2-(4'-N,N-dimethylaminophenyl)furan (100191-85-3)

Guidance literature:

With carbon monoxide; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane; at 0 ℃; for 30h; under 760 Torr;

DOI:10.3987/com-02-s44

Reference yield: 65.0%

fur-2-ylboronic acid (13331-23-2) + 4-bromo-N,N-dimethylaniline (586-77-6) → 2-(4'-N,N-dimethylaminophenyl)furan (100191-85-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

DOI:10.1246/cl.210420

Reference yield: 32.0%

furan (110-00-9) + 4-chloro-N,N-dimethylaniline (698-69-1) → 2-(4'-N,N-dimethylaminophenyl)furan (100191-85-3) + N,N-dimethyl-aniline (121-69-7,77733-26-7) + 3-(4'-N,N-dimethylaminophenyl)furan + N,N-dimethyl-2-(4'-(dimethylamino)phenyl)-4-chloroaniline

Guidance literature:

With potassium carbonate; In acetonitrile; for 3h; Irradiation;

DOI:10.1016/S0040-4020(00)00909-1

upstream raw materials:

furan

4-chloro-N,N-dimethylaniline

propargyl p-toluenesulfonate

4-(furan-2-yl)aniline

Refernces

• 1、 Abe, Manabu,Chitose, Youhei,Lin, Tzu-Chau,Pham, Thuy Thi Thu,Tam, Tran Thi Thanh,Tseng, Wei-Lun. "Impact of Five-membered Heterocyclic Rings on Photophysical Properties including Two-photon Absorption Character". supporting information. p. 1810 - 1813. Retrieved 2021/10/27.
• 2、 Guizzardi, Benedetta,Mella, Mariella,Fagnoni, Maurizio,Albini, Angelo. "Easy photochemical preparation of 2-dimethylaminophenylfurans, -pyrroles and -thiophenes". . p. 9383 - 9389. Retrieved 2007/10/03.