3-Pyrrolidinecarboxylic acid, 1-cyclohexyl-5-oxo-, methyl ester

Base Information

• Chemical Name: 3-Pyrrolidinecarboxylic acid, 1-cyclohexyl-5-oxo-, methyl ester
• CAS No.: 100252-83-3
• Molecular Formula: C12H19NO3
• Molecular Weight: 225.288
• Mol file: 100252-83-3.mol

Synonyms:methyl 1-cyclohexyl-5-oxopyrrolidine-3-carboxylate;1-Cyclohexyl-3-methoxycarbonyl-pyrrolidon-(5);1-Cyclohexyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester;

Chemical Property of 3-Pyrrolidinecarboxylic acid, 1-cyclohexyl-5-oxo-, methyl ester

Chemical Property:

• Boiling Point: 122 - 124 °C (0.06 mmHg)
• PSA: 46.61000
• LogP: 1.27850

Purity/Quality:

99% ^*data from raw suppliers

Methyl 1-cyclohexyl-5-oxopyrrolidine-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyrrolidinecarboxylic acid, 1-cyclohexyl-5-oxo-, methyl ester

There total 2 articles about 3-Pyrrolidinecarboxylic acid, 1-cyclohexyl-5-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Dimethyl itakonate (617-52-7) + cyclohexylamine (108-91-8,157973-60-9) → 1-cyclohexyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (100252-83-3)

Guidance literature:

In methanol; for 16h; Heating / reflux;

Reference yield:

→ 1-cyclohexyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (100252-83-3)

Guidance literature:

Itaconsaeure-dimethylester, Cyclohexylamin, abs. Me (25grad, 12h; dann 70grad, 2-3h);

DOI:10.1021/jo01064a051

Reference yield:

1-cyclohexyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (100252-83-3) → 1-cyclohexyl-4-(hydroxymethyl)pyrrolidin-2-one (886615-26-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 16h;

upstream raw materials:

Dimethyl itakonate

cyclohexylamine

Downstream raw materials:

1-cyclohexyl-4-(hydroxymethyl)pyrrolidin-2-one

Refernces