(S)-Lisofylline

Base Information

Chemical Name:(S)-Lisofylline
CAS No.:100324-80-9
Molecular Formula:C13H20N4O3
Molecular Weight:280.32300
Hs Code.:
Mol file:100324-80-9.mol

Synonyms:Amendol;Di-O-methyl-osajetin;

Suppliers and Price of (S)-Lisofylline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
(S)-Lisofylline ≥98%
5mg
$ 257.00

Cayman Chemical
(S)-Lisofylline ≥98%
1mg
$ 57.00

Cayman Chemical
(S)-Lisofylline ≥98%
10mg
$ 456.00

ApexBio Technology
(S)-Lisofylline
10mg
$ 632.00

ApexBio Technology
(S)-Lisofylline
5mg
$ 356.00

ApexBio Technology
(S)-Lisofylline
1mg
$ 79.00

AK Scientific
3,7-Dihydro-1-(5S-hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6-dione
1mg
$ 176.00

Total 6 raw suppliers

Chemical Property of (S)-Lisofylline

Chemical Property:

PSA：82.05000
LogP:-0.01520
Solubility.:≤15mg/ml in ethanol;3mg/ml in DMSO;12mg/ml in dimethyl formamide

Purity/Quality:

97% ^*data from raw suppliers

(S)-Lisofylline ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

General Description (S)-Lisofylline, also known as Amendol or Di-O-methyl-osajetin, is a chiral metabolite of pentoxifylline with demonstrated anti-inflammatory and anti-fibrotic properties. It exhibits potential therapeutic benefits in conditions like Crohn's disease by attenuating inflammation and fibrosis, as evidenced by reductions in collagen deposition and colon damage in experimental models. Additionally, (S)-Lisofylline has been studied in prodrug formulations to enhance pharmacokinetic profiles, showing promise in diabetes management by improving insulin levels and β-cell integrity. Its interaction with ciprofloxacin suggests enhanced bioavailability, while its role as a phosphodiesterase inhibitor highlights its ability to elevate cAMP levels, contributing to its anti-inflammatory effects. Enantioselective synthesis methods have been developed to produce (S)-Lisofylline with high purity, further supporting its pharmacological applications.

Technology Process of (S)-Lisofylline

There total 21 articles about (S)-Lisofylline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 154719-57-0
1-(5,6-oxidohexyl)-3,7-dimethylxanthine

: ammonium chloride

: 6493-06-7,100324-80-9,100324-81-0
1-(5-hydroxyhexyl)theobromine

Guidance literature:: With sodium borohydrid; In ethanol;

Reference yield: 95.0%

: 6493-05-6
pentoxyphylline

: 6493-06-7,100324-80-9,100324-81-0
1-(5-hydroxyhexyl)theobromine

Guidance literature:: With methanol; sodium tetrahydroborate; In acetonitrile; at 0 - 20 ℃; for 3.33333h;
DOI:10.1002/ejoc.202001602

Reference yield: 95.0%

: 6493-05-6
pentoxyphylline

: 100324-81-0
lisofylline

: 100324-80-9
(+)-(S)-3,7-dimethyl-1-(5-hydroxyhexyl)-3,7-dihydropurine-2,6-dione

Guidance literature:: With Saccharomyces cerevisiae KKPU; In phosphate buffer; at 30 ℃; for 120h; Further Variations:; Solvents; Temperatures; Reagents; time; Product distribution;