4-S-pivaloyloxymethyl-2'-O-tert-butyldimethylsilyl-5'-O-dimethoxytrityl-4-thiouridine

Base Information

Chemical Name:4-S-pivaloyloxymethyl-2'-O-tert-butyldimethylsilyl-5'-O-dimethoxytrityl-4-thiouridine
CAS No.:219709-48-5
Molecular Formula:C₄₂H₅₄N₂O₉SSi
Molecular Weight:791.05
Hs Code.:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-S-pivaloyloxymethyl-2'-O-tert-butyldimethylsilyl-5'-O-dimethoxytrityl-4-thiouridine

Chemical Property:

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Technology Process of 4-S-pivaloyloxymethyl-2'-O-tert-butyldimethylsilyl-5'-O-dimethoxytrityl-4-thiouridine

There total 5 articles about 4-S-pivaloyloxymethyl-2'-O-tert-butyldimethylsilyl-5'-O-dimethoxytrityl-4-thiouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 219709-47-4
4-S-pivaloyloxymethyl-5'-O-dimethoxytrityl-3'-O-tert-butyldimethylsilyl-4-thiouridine

: 219709-48-5
4-S-pivaloyloxymethyl-2'-O-tert-butyldimethylsilyl-5'-O-dimethoxytrityl-4-thiouridine

Guidance literature:: With triethylamine; In ethanol; for 2h; Ambient temperature;
DOI:10.1080/07328319808004327

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 219709-48-5
4-S-pivaloyloxymethyl-2'-O-tert-butyldimethylsilyl-5'-O-dimethoxytrityl-4-thiouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / pyridine / Ambient temperature; overnight

2: 1.) imidazole, 2.) K₂CO₃ / 1.) DMF, 24 h, rt, 2.) acetone, 24 h

With 1H-imidazole; potassium carbonate; In pyridine;
DOI:10.1080/07328319808004327

Reference yield:

: 13957-31-8
4-thiouridine

: 219709-48-5
4-S-pivaloyloxymethyl-2'-O-tert-butyldimethylsilyl-5'-O-dimethoxytrityl-4-thiouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / pyridine / Ambient temperature; overnight

2: 1.) imidazole, 2.) K₂CO₃ / 1.) DMF, 24 h, rt, 2.) acetone, 24 h

With 1H-imidazole; potassium carbonate; In pyridine;
DOI:10.1080/07328319808004327