Technology Process of ethyl 3-cyclopropylamino-2-(5-fluoro-2,4-dinitrobenzoyl)acrylate
There total 6 articles about ethyl 3-cyclopropylamino-2-(5-fluoro-2,4-dinitrobenzoyl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 81 percent / nitric acid (d=1.42), conc. sulphuric acid / 1.) not over 35 deg C; 2.) 30 min, room temp.
2: 53 percent / conc. sulphuric acid, anhydrous chromic acid / H2O / 1.) 20 min, -6 deg C - 0 deg C; 2.) room temp., 3.5 h.
3: 75 percent / SOCl2 / 2.5 h / Heating
4: 1.) Mg / 1.) C2H5OH, CCl4, ether; 2.) THF, 20 min 4 deg C - 18 deg C, 1 h room temp.
5: 71 percent / p-toluenesulfonic acid / H2O / 1 h / 125 °C
6: 1.) acetic anhydride / 1.) 120 deg C, 1 h; 2.) ethanol, ether, room temp., 10 min.
With
thionyl chloride; sulfuric acid; nitric acid; acetic anhydride; chromic acid; toluene-4-sulfonic acid; magnesium;
In
water;
DOI:10.1002/jhet.5570240134
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 53 percent / conc. sulphuric acid, anhydrous chromic acid / H2O / 1.) 20 min, -6 deg C - 0 deg C; 2.) room temp., 3.5 h.
2: 75 percent / SOCl2 / 2.5 h / Heating
3: 1.) Mg / 1.) C2H5OH, CCl4, ether; 2.) THF, 20 min 4 deg C - 18 deg C, 1 h room temp.
4: 71 percent / p-toluenesulfonic acid / H2O / 1 h / 125 °C
5: 1.) acetic anhydride / 1.) 120 deg C, 1 h; 2.) ethanol, ether, room temp., 10 min.
With
thionyl chloride; sulfuric acid; acetic anhydride; chromic acid; toluene-4-sulfonic acid; magnesium;
In
water;
DOI:10.1002/jhet.5570240134
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / SOCl2 / 2.5 h / Heating
2: 1.) Mg / 1.) C2H5OH, CCl4, ether; 2.) THF, 20 min 4 deg C - 18 deg C, 1 h room temp.
3: 71 percent / p-toluenesulfonic acid / H2O / 1 h / 125 °C
4: 1.) acetic anhydride / 1.) 120 deg C, 1 h; 2.) ethanol, ether, room temp., 10 min.
With
thionyl chloride; acetic anhydride; toluene-4-sulfonic acid; magnesium;
In
water;
DOI:10.1002/jhet.5570240134
