methyl 6-amino-4-(3-bromophenyl)-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4H-pyran-3-carboxylate

Base Information

• Chemical Name: methyl 6-amino-4-(3-bromophenyl)-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4H-pyran-3-carboxylate
• CAS No.: 354556-65-3
• Molecular Formula: C₂₆H₂₃BrN₄O₃S
• Molecular Weight: 551.464
• Mol file: 354556-65-3.mol

Synonyms:

Chemical Property of methyl 6-amino-4-(3-bromophenyl)-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4H-pyran-3-carboxylate

Chemical Property:

Purity/Quality:

METHYL-6-AMINO-4-(3-BROMOPHENYL)-5-CYANO-2-(((3-CYANO-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA(B)PYRIDIN-2-YL)SULFANYL)METHYL)-4H-PYRAN-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-amino-4-(3-bromophenyl)-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4H-pyran-3-carboxylate

There total 5 articles about methyl 6-amino-4-(3-bromophenyl)-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4H-pyran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-thioxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[b]pyridine-3-carbonitrile (123413-84-3) + 6-amino-4-(3-bromo-phenyl)-2-chloromethyl-5-cyano-4H-pyran-3-carboxylic acid methyl ester (625366-60-1) → 6-amino-4-(3-bromo-phenyl)-5-cyano-2-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanylmethyl)-4H-pyran-3-carboxylic acid methyl ester (354556-65-3)

Guidance literature:

In ethanol; at 40 - 45 ℃;

DOI:10.1023/B:RUCB.0000011877.60574.34

Reference yield: 72.0%

2-(3-bromobenzylidene)malononitrile (2972-74-9) + 4-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanyl)-3-oxo-butyric acid methyl ester → 6-amino-4-(3-bromo-phenyl)-5-cyano-2-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanylmethyl)-4H-pyran-3-carboxylic acid methyl ester (354556-65-3)

Guidance literature:

With triethylamine; In ethanol; Heating;

DOI:10.1023/B:RUCB.0000011877.60574.34

Reference yield:

Methyl 4-chloroacetoacetate (32807-28-6,935731-94-5) → 6-amino-4-(3-bromo-phenyl)-5-cyano-2-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanylmethyl)-4H-pyran-3-carboxylic acid methyl ester (354556-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / Et₃N / ethanol / Heating

With triethylamine; In ethanol;

DOI:10.1023/B:RUCB.0000011877.60574.34

upstream raw materials:

2-(3-bromobenzylidene)malononitrile

2-thioxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[b]pyridine-3-carbonitrile

6-amino-4-(3-bromo-phenyl)-2-chloromethyl-5-cyano-4H-pyran-3-carboxylic acid methyl ester

m-bromobenzoic aldehyde