TR-2379 free base

Base Information

Chemical Name:TR-2379 free base
CAS No.:23548-26-7
Molecular Formula:C₂₂H₂₆N₂O
Molecular Weight:334.461
Hs Code.:
UNII:60MGA26ZMB
ChEMBL ID:CHEMBL132013

Synonyms:TR-2379 free base;60MGA26ZMB;UNII-60MGA26ZMB;Propanamide, N-(1,3,4,6,7,11b-hexahydro-2H-benzo(a)quinolizin-2-yl)-N-phenyl-, trans-;Propionanilide, N-(1,3,4,6,7,11b-hexahydro-2H-benzo(a)quinolizin-2-yl)-, trans-;trans-N-(1,3,4,6,7,11b-Hexahydro-2H-benzo(a)quinolizin-2-yl)-N-phenylpropionamide;23548-26-7;CHEMBL132013;Q27263241

Suppliers and Price of TR-2379 free base

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of TR-2379 free base

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:334.204513457
Heavy Atom Count:25
Complexity:459

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)N(C1CCN2CCC3=CC=CC=C3C2C1)C4=CC=CC=C4
Isomeric SMILES:CCC(=O)N([C@@H]1CCN2CCC3=CC=CC=C3[C@@H]2C1)C4=CC=CC=C4

Technology Process of TR-2379 free base

There total 4 articles about TR-2379 free base which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 79-03-8
propionyl chloride

: 34375-63-8,75688-98-1
(2S,11bS)-1,3,4,6,7,11b-Hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl-phenyl-amine

: 23548-26-7,23548-27-8,66142-87-8
N-(2α,11bα)-(1,3,4,6,7,11b-hexahydro-2H-benzo quinolizin-2-yl)-N-phenylpropanamide

Guidance literature:: In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00133a017

Reference yield:

: 715-52-6
1,3,4,6,7,11b-hexahydro-2oxo-2H-benzo[a]quinolizine

: 23548-26-7,23548-27-8,66142-87-8
N-(2α,11bα)-(1,3,4,6,7,11b-hexahydro-2H-benzo quinolizin-2-yl)-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH / toluene / 21 h / Heating

2: L-Selectride / toluene / 1.5 h

3: 76 percent / CH₂Cl₂ / 16 h / Ambient temperature

With L-Selectride; toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1021/jm00133a017

Reference yield:

: 23556-05-0
[1,3,4,6,7,11b-Hexahydro-pyrido[2,1-a]isoquinolin-(2E)-ylidene]-phenyl-amine

: 23548-26-7,23548-27-8,66142-87-8
N-(2α,11bα)-(1,3,4,6,7,11b-hexahydro-2H-benzo quinolizin-2-yl)-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: L-Selectride / toluene / 1.5 h

2: 76 percent / CH₂Cl₂ / 16 h / Ambient temperature

With L-Selectride; In dichloromethane; toluene;
DOI:10.1021/jm00133a017