Methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate

Base Information

Chemical Name:Methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate
CAS No.:100445-44-1
Molecular Formula:C11H13NO2
Molecular Weight:191.23
Hs Code.:
DSSTox Substance ID:DTXSID60440706
Nikkaji Number:J1.051.330H
Wikidata:Q82257079
Mol file:100445-44-1.mol

Synonyms:Methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate;100445-44-1;2-Quinolinecarboxylic acid, 5,6,7,8-tetrahydro-, methyl ester;SCHEMBL5053548;DTXSID60440706;F53858;5,6,7,8-Tetrahydro-2-quinolinecarboxylic acid methyl ester

Suppliers and Price of Methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:191.094628657
Heavy Atom Count:14
Complexity:217

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=NC2=C(CCCC2)C=C1

Technology Process of Methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate

There total 2 articles about Methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 19575-07-6
quinoline-2-carboxylic acid methyl ester

: 63430-79-5
1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester

: 100445-44-1
methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate

Guidance literature:: With hydrogen; platinum(IV) oxide; In trifluoroacetic acid; at 20 ℃; for 4h; under 760.051 Torr;
DOI:10.1021/jo026258k

Reference yield:

: 15366-34-4
methyl 1H-pyrazole 3-carboxylate

: 100445-44-1
methyl 5,6,7,8-tetrahydroquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium periodate / dichloromethane; water / 2 h / 0 - 20 °C

3.1: chloroform / 2 h / 20 - 60 °C / Molecular sieve

With sodium periodate; sodium hydride; In dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol502436n