(R)-N-(1-(4-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine

Base Information

Chemical Name:(R)-N-(1-(4-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine
CAS No.:1393180-45-4
Molecular Formula:C₂₁H₁₉N₇
Molecular Weight:369.429
Hs Code.:

Synonyms:

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Chemical Property of (R)-N-(1-(4-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine

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Technology Process of (R)-N-(1-(4-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine

There total 5 articles about (R)-N-(1-(4-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62-53-3
aniline

: 1393180-45-4
(R)-N-(1-(4-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 110 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 46 h / 20 °C

4: acetic acid / 20.75 h / 20 - 70 °C

5: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 h / 100 °C / Sealed

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; caesium carbonate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; In dichloromethane; ethyl acetate; toluene; butan-1-ol;

Reference yield:

: 52414-97-8
1-bromo-3-methyl-2-nitro-benzene

: 1393180-45-4
(R)-N-(1-(4-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 110 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 46 h / 20 °C

4: acetic acid / 20.75 h / 20 - 70 °C

5: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 h / 100 °C / Sealed

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; caesium carbonate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; In dichloromethane; ethyl acetate; toluene; butan-1-ol;

Reference yield:

: 220495-97-6
3-methyl-2-nitrodiphenylamine

: 1393180-45-4
(R)-N-(1-(4-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 46 h / 20 °C

3: acetic acid / 20.75 h / 20 - 70 °C

4: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 h / 100 °C / Sealed

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; butan-1-ol;