N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Base Information

Chemical Name:N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide
CAS No.:198703-62-7
Molecular Formula:C₃₅H₄₀N₆O₅Si
Molecular Weight:652.825
Hs Code.:

N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

There total 6 articles about N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199581-55-0
N-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-methyleneaminooxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 198703-62-7
N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; Yield given; pH 4;
DOI:10.1080/07328319708006242

Reference yield:

: 2140-79-6
2'-O-methyl adenosine

: 198703-62-7
N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: PPh₃ / tetrahydrofuran

2: imidazole / dimethylformamide / 18 h

3: methylhydrazine / CH₂Cl₂ / 1 h / 0 °C

4: methanol; ethyl acetate / 0.5 h / 40 °C

5: pyridine / 18 h / 0 - 20 °C

6: NaBH₃CN, HCl / methanol / pH 4

With pyridine; 1H-imidazole; hydrogenchloride; sodium cyanoborohydride; triphenylphosphine; methylhydrazine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006242

Reference yield:

: 183737-02-2
2'-O-Methyl-5'-O-phthalimidoadenosine

: 198703-62-7
N-(9-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / dimethylformamide / 18 h

2: methylhydrazine / CH₂Cl₂ / 1 h / 0 °C

3: methanol; ethyl acetate / 0.5 h / 40 °C

4: pyridine / 18 h / 0 - 20 °C

5: NaBH₃CN, HCl / methanol / pH 4

With pyridine; 1H-imidazole; hydrogenchloride; sodium cyanoborohydride; methylhydrazine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006242