mephenesin

Base Information

• Chemical Name: mephenesin
• CAS No.: 134254-23-2
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.219
• Mol file: 134254-23-2.mol

Synonyms:

Chemical Property of mephenesin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of mephenesin

There total 8 articles about mephenesin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-cresol (106-44-5) + oxiranyl-methanol (556-52-5) → mephenesin (134254-23-2,148552-90-3,17131-24-7)

Guidance literature:

With C₁₆H₂₈N₂O₂; In ethanol; at 50 ℃; for 12h; Inert atmosphere;

DOI:10.1080/00397910903419878

Reference yield:

cresyl-glicidyl ether (2186-24-5) → mephenesin (134254-23-2,148552-90-3,17131-24-7)

Guidance literature:

With sulfuric acid; for 1h; Ambient temperature;

Reference yield:

cresyl-glicidyl ether (2186-24-5) → mephenesin (134254-23-2,148552-90-3,17131-24-7) + (2S)-(+)-3-[4'-(methyl)-phenoxy]-1,2-epoxypropane (101693-40-7) + (R)-1,2-epoxy-3-(4-methylphenoxy)propane

Guidance literature:

With Bacillus megaterium ECU₁₀₀₁ epoxide hydrolase; In potassium phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 0.833333h; pH=7; optical yield given as %ee; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/adsc.201100031

upstream raw materials:

p-cresol

glycerol

cresyl-glicidyl ether

epichlorohydrin

Downstream raw materials:

2-phenyl-4-p-tolyloxymethyl-[1,3,2]dioxaborolane

2-(4-methylphenoxy)acetaldehyde

Acetic acid (S)-2-hydroxy-3-p-tolyloxy-propyl ester

Acetic acid (R)-2-hydroxy-3-p-tolyloxy-propyl ester

Refernces

• 1、 Aral, Tarik,Karakaplan, Mehmet,Hosgoeren, Halil. "Asymmetric organocatalytic efficiency of synthesized chiral β-amino alcohols in ring-opening of glycidol with phenols". experimental part. p. 794 - 802. Retrieved 2012/08/28.
• 2、 Turgut, Yilmaz,Aral, Tarik,Karakaplan, Mehmet,Deniz, Pinar,Hosgoren, Halil. "Synthesis of C2-symmetric chiral amino alcohols: Their usage as organocatalysts for enantioselective opening of epoxide ring". scheme or table. p. 3365 - 3377. Retrieved 2011/01/04.