2-NAPHTHYLOXYETHANENITRILE

Base Information

• Chemical Name: 2-NAPHTHYLOXYETHANENITRILE
• CAS No.: 104096-13-1
• Molecular Formula: C₁₂H₉NO
• Molecular Weight: 183.21
• Mol file: 104096-13-1.mol

Synonyms:

Chemical Property of 2-NAPHTHYLOXYETHANENITRILE

Chemical Property:

• Boiling Point: 356.1±15.0 °C(Predicted)
• Density: 1.163±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-NAPHTHYLOXYETHANENITRILE

There total 2 articles about 2-NAPHTHYLOXYETHANENITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

α-naphthol (90-15-3) + chloroacetonitrile (107-14-2) → 2-(naphthalen-1-yloxy)acetonitrile (104096-13-1)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/ol035223j

Reference yield:

→ 2-(naphthalen-1-yloxy)acetonitrile (104096-13-1)

Guidance literature:

Reference yield:

2-(naphthalen-1-yloxy)acetonitrile (104096-13-1) → 2-(2-(naphthalen-2-yloxy)ethylcarbamoyl)phenyl acetate (1463964-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 °C

1.2: 0 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1002/cmdc.201200407

upstream raw materials:

α-naphthol

chloroacetonitrile

Downstream raw materials:

2-[1]naphthyloximethyl-4,5-dihydro-1H-imidazole

2-(2-(naphthalen-2-yloxy)ethylcarbamoyl)phenyl acetate

2-hydroxy-N-(2-(naphthalen-1-yloxy)ethyl)benzamide