3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

Base Information

Chemical Name:3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride
CAS No.:123724-82-3
Molecular Formula:C₂₀H₂₃N₉O₄S*ClH
Molecular Weight:521.987
Hs Code.:

3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

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Chemical Property of 3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

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Technology Process of 3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

There total 9 articles about 3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 64-18-6
formic acid

: 123724-98-1
2-[(4-Amino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-thiazole-4-carboxylic acid [5-(2-carbamimidoyl-ethylcarbamoyl)-1-methyl-1H-pyrrol-3-yl]-amide; hydrochloride

: 123724-82-3
3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; at -40 ℃; for 0.5h;
DOI:10.1021/jo00289a057

Reference yield:

: 13138-78-8
1-methyl-4-nitro-pyrrol-2-carboxylic acid

: 123724-82-3
3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 1.5 h / Heating

2: 90 percent / pyridine / tetrahydrofuran / 10 h / Ambient temperature

3: 95 percent / NaOH / methanol; H₂O / 1.5 h / Ambient temperature

4: 68 percent / HOBT, DCC / dimethylsulfoxide; dimethylformamide / 10 h / Ambient temperature

5: hydrogen / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

6: 40 percent / carbonyldiimidazole / tetrahydrofuran; methanol / 0.5 h / -40 °C

With pyridine; sodium hydroxide; thionyl chloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00289a057

Reference yield:

: 123724-94-7
2-[(1-methyl-4-nitro-1H-pyrrol-2-ylcarbonyl)amino]-1,3-thiazole-4-carboxylic acid

: 123724-82-3
3-<1-methyl-4-<2-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>thiazole-4-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / HOBT, DCC / dimethylsulfoxide; dimethylformamide / 10 h / Ambient temperature

2: hydrogen / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 40 percent / carbonyldiimidazole / tetrahydrofuran; methanol / 0.5 h / -40 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00289a057